Abstract
On the basis of the potent biological activity of cyclopentenyl- pyrimidines, fluorocyclopentenyl-pyrimidines were designed and synthesized from d-ribose. Among these, the cytosine derivative 5a showed highly potent antigrowth effects in a broad range of tumor cell lines and very potent antitumor activity in a nude mouse tumor xenograft model implanted with A549 human lung cancer cells. However, its 2′-deoxycytidine derivative 5b did not show any antigrowth effects, indicating that 2′-hydroxyl group is essential for the biological activity.
Original language | English |
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Pages (from-to) | 4521-4525 |
Number of pages | 5 |
Journal | Journal of Medicinal Chemistry |
Volume | 55 |
Issue number | 9 |
DOIs | |
State | Published - 10 May 2012 |