TY - JOUR
T1 - Folate-conjugated nanovehicles
T2 - Strategies for cancer therapy
AU - Farran, Batoul
AU - Montenegro, Raquel Carvalho
AU - Kasa, Prameswari
AU - Pavitra, Eluri
AU - Huh, Yun Suk
AU - Han, Young Kyu
AU - Kamal, Mohammad Amjad
AU - Nagaraju, Ganji Purnachandra
AU - Rama Raju, Ganji Seeta
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2020/2
Y1 - 2020/2
N2 - Cancer theranostics represents a strategy that aims at combining diagnosis with therapy through the simultaneous imaging and targeted delivery of therapeutics to cancer cells. Recently, the folate receptor alpha has emerged as an attractive theranostic target due to its overexpression in multiple solid tumors and its great functional versatility. In fact, it can be incorporated into folate-conjugated nano-systems for imaging and drug delivery. Hence, it can be used along the line of personalized clinical strategies as both an imaging tool and a delivery method ensuring the selective transport of treatments to tumor cells, thus highlighting its theranostic qualities. In this review, we will explore these theranostic characteristics in detail and assess their clinical potential. We will also discuss the technological advances that have allowed the design of sophisticated folate-based nanocarriers harboring various chemical properties and suited for the transport of various therapeutic agents.
AB - Cancer theranostics represents a strategy that aims at combining diagnosis with therapy through the simultaneous imaging and targeted delivery of therapeutics to cancer cells. Recently, the folate receptor alpha has emerged as an attractive theranostic target due to its overexpression in multiple solid tumors and its great functional versatility. In fact, it can be incorporated into folate-conjugated nano-systems for imaging and drug delivery. Hence, it can be used along the line of personalized clinical strategies as both an imaging tool and a delivery method ensuring the selective transport of treatments to tumor cells, thus highlighting its theranostic qualities. In this review, we will explore these theranostic characteristics in detail and assess their clinical potential. We will also discuss the technological advances that have allowed the design of sophisticated folate-based nanocarriers harboring various chemical properties and suited for the transport of various therapeutic agents.
KW - Cancer therapy
KW - Folate receptor
KW - Nanoparticles
KW - Targeted delivery
UR - http://www.scopus.com/inward/record.url?scp=85074166906&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2019.110341
DO - 10.1016/j.msec.2019.110341
M3 - Review article
C2 - 31761235
AN - SCOPUS:85074166906
SN - 0928-4931
VL - 107
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
M1 - 110341
ER -