Formaldehyde exposure and leukemia risk: a comprehensive review and network-based toxicogenomic approach

Doo Seok Kang, Hyun Soo Kim, Jong Hyeon Jung, Cheol Min Lee, Yeon Soon Ahn, Young Rok Seo

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations

Abstract

Formaldehyde is a widely used but highly reactive and toxic chemical. The International Agency for Research on Cancer classifies formaldehyde as a Group 1 carcinogen, based on nasopharyngeal cancer and leukemia studies. However, the correlation between formaldehyde exposure and leukemia incidence is a controversial issue. To understand the association between formaldehyde exposure and leukemia, we explored biological networks based on formaldehyde-related genes retrieved from public and commercial databases. Through the literature-based network approach, we summarized qualitative associations between formaldehyde exposure and leukemia. Our results indicate that oxidative stress-mediated genetic changes induced by formaldehyde could disturb the hematopoietic system, possibly leading to leukemia. Furthermore, we suggested major genes that are thought to be affected by formaldehyde exposure and associated with leukemia development. Our suggestions can be used to complement experimental data for understanding and identifying the leukemogenic mechanism of formaldehyde.

Original languageEnglish
Article number13
JournalGenes and Environment
Volume43
Issue number1
DOIs
StatePublished - Dec 2021

Keywords

  • Biological network analysis
  • Carcinogenicity
  • Formaldehyde
  • Leukemia
  • Toxicogenomics

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