TY - JOUR
T1 - Fructose-1,6-bisphosphatase Inhibitors
T2 - A review of recent (2000-2017) advances and structure-activity relationship studies
AU - Singh, Sarbjit
AU - Harmalkar, Dipesh S.
AU - Choi, Yongseok
AU - Lee, Kyeong
N1 - Publisher Copyright:
© 2019 Bentham Science Publishers
PY - 2019
Y1 - 2019
N2 - Diabetes mellitus, commonly referred to as diabetes, is the 8th leading cause of death worldwide. As of 2015, approximately 415 million people were estimated to be diabetic worldwide, type 2 diabetes being the most common accounting for approximately 90-95% of all diagnosed cases with increasing prevalence. Fructose-1,6-bisphosphatase is one of the important therapeutic targets recently discovered to treat this chronic disease. In this focused review, we have highlighted recent advances and structure-activity relationship studies in the discovery and development of different fructose-1,6-bisphosphatase inhibitors reported since the year 2000.
AB - Diabetes mellitus, commonly referred to as diabetes, is the 8th leading cause of death worldwide. As of 2015, approximately 415 million people were estimated to be diabetic worldwide, type 2 diabetes being the most common accounting for approximately 90-95% of all diagnosed cases with increasing prevalence. Fructose-1,6-bisphosphatase is one of the important therapeutic targets recently discovered to treat this chronic disease. In this focused review, we have highlighted recent advances and structure-activity relationship studies in the discovery and development of different fructose-1,6-bisphosphatase inhibitors reported since the year 2000.
KW - 6-bisphosphatase inhibitors
KW - Adenosine 5’-monophosphate
KW - Chronic disease
KW - Diabetes mellitus
KW - Fructose-1
KW - Hyperglycemia
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85075086237&partnerID=8YFLogxK
U2 - 10.2174/0929867325666180831133734
DO - 10.2174/0929867325666180831133734
M3 - Review article
C2 - 30182843
AN - SCOPUS:85075086237
SN - 0929-8673
VL - 26
SP - 5542
EP - 5563
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 29
ER -