Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: A case report

Angelica Garcia; Nam Joon Yi; Kyoung Bun Lee; Jeong Moo Lee; Young Rok Choi; Suk Won Suh; Tae You; Kwang Woong Lee; June Dong Park; Hyoung Jin Kang; Joon Gon Kim; Eun Kyeong Kang; Geun Hong; Kyung Suk Suh

doi:10.1111/petr.12343

Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: A case report

Angelica Garcia
, Nam Joon Yi
, Kyoung Bun Lee
, Jeong Moo Lee
, Young Rok Choi
, Suk Won Suh
, Tae You
, Kwang Woong Lee
, June Dong Park
, Hyoung Jin Kang
, Joon Gon Kim
, Eun Kyeong Kang
, Geun Hong
, Kyung Suk Suh

Department of Medicine

Seoul National University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Dapsone is a sulfone-type drug used widely for different infectious, immune, and hypersensitivity disorders as an antibacterial treatment alone or in combination for leprosy and sometimes for infected skin lesions. DHS is a severe idiosyncratic adverse reaction with multi-organ involvement. However, acute necrotic hepatitis requiring an emergent LT is rare. Herein, we report a case of 12-yr-old girl who suffered from fulminant hepatitis and multi-organ failure due to DHS for PPD. She was saved by emergent LDLT. A high index of suspicion and rapid diagnosis are necessary not to miss this potentially lethal but rare disease.

Original language	English
Pages (from-to)	E240-E245
Journal	Pediatric Transplantation
Volume	18
Issue number	7
DOIs	https://doi.org/10.1111/petr.12343
State	Published - 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Dapsone hypersensitivity syndrome
Fulminant hepatitis
Liver transplant
Pigmented purpuric dermatosis

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10.1111/petr.12343

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Garcia, A., Yi, N. J., Lee, K. B., Lee, J. M., Choi, Y. R., Suh, S. W., You, T., Lee, K. W., Park, J. D., Kang, H. J., Kim, J. G., Kang, E. K., Hong, G., & Suh, K. S. (2014). Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: A case report. Pediatric Transplantation, 18(7), E240-E245. https://doi.org/10.1111/petr.12343

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title = "Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: A case report",

abstract = "Dapsone is a sulfone-type drug used widely for different infectious, immune, and hypersensitivity disorders as an antibacterial treatment alone or in combination for leprosy and sometimes for infected skin lesions. DHS is a severe idiosyncratic adverse reaction with multi-organ involvement. However, acute necrotic hepatitis requiring an emergent LT is rare. Herein, we report a case of 12-yr-old girl who suffered from fulminant hepatitis and multi-organ failure due to DHS for PPD. She was saved by emergent LDLT. A high index of suspicion and rapid diagnosis are necessary not to miss this potentially lethal but rare disease.",

keywords = "Dapsone hypersensitivity syndrome, Fulminant hepatitis, Liver transplant, Pigmented purpuric dermatosis",

author = "Angelica Garcia and Yi, \{Nam Joon\} and Lee, \{Kyoung Bun\} and Lee, \{Jeong Moo\} and Choi, \{Young Rok\} and Suh, \{Suk Won\} and Tae You and Lee, \{Kwang Woong\} and Park, \{June Dong\} and Kang, \{Hyoung Jin\} and Kim, \{Joon Gon\} and Kang, \{Eun Kyeong\} and Geun Hong and Suh, \{Kyung Suk\}",

note = "Publisher Copyright: {\textcopyright} 2014 John Wiley \& Sons A/S. Published by John Wiley \& Sons Ltd.",

year = "2014",

doi = "10.1111/petr.12343",

language = "English",

volume = "18",

pages = "E240--E245",

journal = "Pediatric Transplantation",

issn = "1397-3142",

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T1 - Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation

T2 - A case report

AU - Garcia, Angelica

AU - Yi, Nam Joon

AU - Lee, Kyoung Bun

AU - Lee, Jeong Moo

AU - Choi, Young Rok

AU - Suh, Suk Won

AU - You, Tae

AU - Lee, Kwang Woong

AU - Park, June Dong

AU - Kang, Hyoung Jin

AU - Kim, Joon Gon

AU - Kang, Eun Kyeong

AU - Hong, Geun

AU - Suh, Kyung Suk

PY - 2014

Y1 - 2014

N2 - Dapsone is a sulfone-type drug used widely for different infectious, immune, and hypersensitivity disorders as an antibacterial treatment alone or in combination for leprosy and sometimes for infected skin lesions. DHS is a severe idiosyncratic adverse reaction with multi-organ involvement. However, acute necrotic hepatitis requiring an emergent LT is rare. Herein, we report a case of 12-yr-old girl who suffered from fulminant hepatitis and multi-organ failure due to DHS for PPD. She was saved by emergent LDLT. A high index of suspicion and rapid diagnosis are necessary not to miss this potentially lethal but rare disease.

AB - Dapsone is a sulfone-type drug used widely for different infectious, immune, and hypersensitivity disorders as an antibacterial treatment alone or in combination for leprosy and sometimes for infected skin lesions. DHS is a severe idiosyncratic adverse reaction with multi-organ involvement. However, acute necrotic hepatitis requiring an emergent LT is rare. Herein, we report a case of 12-yr-old girl who suffered from fulminant hepatitis and multi-organ failure due to DHS for PPD. She was saved by emergent LDLT. A high index of suspicion and rapid diagnosis are necessary not to miss this potentially lethal but rare disease.

KW - Dapsone hypersensitivity syndrome

KW - Fulminant hepatitis

KW - Liver transplant

KW - Pigmented purpuric dermatosis

UR - https://www.scopus.com/pages/publications/85027928213

U2 - 10.1111/petr.12343

DO - 10.1111/petr.12343

M3 - Article

C2 - 25156688

AN - SCOPUS:85027928213

SN - 1397-3142

VL - 18

SP - E240-E245

JO - Pediatric Transplantation

JF - Pediatric Transplantation

IS - 7

ER -

Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: A case report

Abstract

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Keywords

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