Abstract
A new sorbicillinoid polyketide, dihydrotrichodimerol (2), along with known trichodimerol (1), and rezishanones C (3) and D (4) were isolated by bioassay-guided fractionation from an unidentified fungal strain. Dihydrotrichodimerol (2) specifically activated peroxisome proliferator- activated receptor γ with an ED50 value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors α and δ. On the other hand, compounds 1 and 2 suppressed the production of tumor necrosis factor-α and nitric oxide in LPS-stimulated RAW264.7 cells to a similar extent.
Original language | English |
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Pages (from-to) | 615-620 |
Number of pages | 6 |
Journal | Journal of Antibiotics |
Volume | 58 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2005 |
Keywords
- Nitric oxide
- Peroxisome proliferator-activated receptor γ
- Sorbicillinoid
- Trichodimerol derivative
- Tumor necrosis factor-α