Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ

Dongho Lee; Jeong Hyung Lee; Xing Fu Cai; Jin Chul Shin; Kyeong Lee; Young Soo Hong; Jung Joon Lee

doi:10.1038/ja.2005.84

Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ

Dongho Lee
, Jeong Hyung Lee
, Xing Fu Cai
, Jin Chul Shin
, Kyeong Lee
, Young Soo Hong
, Jung Joon Lee

Department of Pharmacy

Korea Research Institute of Bioscience and Biotechnology

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A new sorbicillinoid polyketide, dihydrotrichodimerol (2), along with known trichodimerol (1), and rezishanones C (3) and D (4) were isolated by bioassay-guided fractionation from an unidentified fungal strain. Dihydrotrichodimerol (2) specifically activated peroxisome proliferator- activated receptor γ with an ED₅₀ value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors α and δ. On the other hand, compounds 1 and 2 suppressed the production of tumor necrosis factor-α and nitric oxide in LPS-stimulated RAW264.7 cells to a similar extent.

Original language	English
Pages (from-to)	615-620
Number of pages	6
Journal	Journal of Antibiotics
Volume	58
Issue number	10
DOIs	https://doi.org/10.1038/ja.2005.84
State	Published - Oct 2005

Keywords

Nitric oxide
Peroxisome proliferator-activated receptor γ
Sorbicillinoid
Trichodimerol derivative
Tumor necrosis factor-α

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10.1038/ja.2005.84

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title = "Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ",

abstract = "A new sorbicillinoid polyketide, dihydrotrichodimerol (2), along with known trichodimerol (1), and rezishanones C (3) and D (4) were isolated by bioassay-guided fractionation from an unidentified fungal strain. Dihydrotrichodimerol (2) specifically activated peroxisome proliferator- activated receptor γ with an ED50 value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors α and δ. On the other hand, compounds 1 and 2 suppressed the production of tumor necrosis factor-α and nitric oxide in LPS-stimulated RAW264.7 cells to a similar extent.",

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author = "Dongho Lee and Lee, \{Jeong Hyung\} and Cai, \{Xing Fu\} and Shin, \{Jin Chul\} and Kyeong Lee and Hong, \{Young Soo\} and Lee, \{Jung Joon\}",

year = "2005",

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AU - Lee, Dongho

AU - Lee, Jeong Hyung

AU - Cai, Xing Fu

AU - Shin, Jin Chul

AU - Lee, Kyeong

AU - Hong, Young Soo

AU - Lee, Jung Joon

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AB - A new sorbicillinoid polyketide, dihydrotrichodimerol (2), along with known trichodimerol (1), and rezishanones C (3) and D (4) were isolated by bioassay-guided fractionation from an unidentified fungal strain. Dihydrotrichodimerol (2) specifically activated peroxisome proliferator- activated receptor γ with an ED50 value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors α and δ. On the other hand, compounds 1 and 2 suppressed the production of tumor necrosis factor-α and nitric oxide in LPS-stimulated RAW264.7 cells to a similar extent.

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KW - Peroxisome proliferator-activated receptor γ

KW - Sorbicillinoid

KW - Trichodimerol derivative

KW - Tumor necrosis factor-α

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Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ

Abstract

Keywords

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