Abstract
Result(s): The mean body mass index (BMI) of the patients was significantly higher than that of the control subjects (22.0 ± 4.1 kg/m2 vs. 20.1 ± 2.5 kg/m2), but most (81.3%) of the patients were not obese. FTO rs9939609 was not significantly associated with PCOS itself. However, a positive correlation was observed between the number of variant alleles and BMI in women with PCOS: Each additional copy of the variant allele increased BMI by a mean (95% confidence interval) of 4.8% (1.4%-8.3%) or 1.11 kg/m2 (1.03-1.20 kg/m2) after adjusting for age. This correlation was not observed in the control subjects.
Conclusion(s): FTO rs9939609 was not a major determinant of PCOS. However, in the women with PCOS who were primarily nonobese, a gene dose effect was observed for BMI. The FTO gene may play an influential role in predisposition to PCOS via an association with obesity.
Objective: To examine the association between fat mass and obesity-associated (FTO) polymorphisms and polycystic ovary syndrome (PCOS) in Korean women.
Design: Case-control study.
Setting: University department of obstetrics and gynecology.
Patient(s): Women with (n = 552) or without (n = 559) PCOS.
Intervention(s): Genotyping was performed.
Main Outcome Measure(s): FTO rs9939609 genotype distribution and correlation between variants in this gene and PCOS phenotypes.
Original language | English |
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Pages (from-to) | 1143-1148.e2 |
Journal | Fertility and Sterility |
Volume | 102 |
Issue number | 4 |
DOIs | |
State | Published - 1 Oct 2014 |
Keywords
- FTO
- obesity
- polycystic ovary syndrome
- single-nucleotide polymorphisms
- type 2 diabetes