Genomic expression responses toward bisphenol-A toxicity in Daphnia magna in terms of reproductive activity

Seok Won Jeong, Sang Min Lee, Seung Shic Yum, Taisen Iguchi, Young Rok Seo

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Bisphenol-A(BPA) classified as an endocrine disruptor that can interfere endocrine system, leading to adverse developmental, reproductive, neurological, and immunological effects in both humans and wildlife. To study the reproductive and geno-toxicological effects of BPA in aquatic ecosystem, we employed Daphnia magna (D. magna) as a test animal model. D. magna in one of the most widely used water species employed in ecotoxicology testing all over the world. As a result, the reproductive activity based on the number of offspring production is significantly reduced toward 21 day exposure to 10 mg/L of BPA, compared with control. Gene expression profiles in response to BPA exposure using DNA microarray analysis was subsequently carried out. Our data showed that expression levels of numerous putative genes with nucleotide sequences homology to animal models including cuticular protein, vitellogenin, protease, ribosomal protein family were altered. These genes which are critically reported in other animal systems could be considered as novel biomarkers in response to BPA exposure.

Original languageEnglish
Pages (from-to)149-158
Number of pages10
JournalMolecular and Cellular Toxicology
Volume9
Issue number2
DOIs
StatePublished - 1 Jun 2013

Keywords

  • Biomarker
  • Bisphenol-A
  • Daphnia magna
  • Microarray
  • Reproduction test

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