Glial fibrillary acidic protein is expressed in the aged rat olfactory epithelium

Min Kyu Kim, Joo Hyun Park, Bum Sun Kwon, Kyeung Min Joo, Jung Soo Pyo, Young Hee Cheon, Tai Kyong Baik, Choong Ik Cha, Sa Sun Cho, Seon Young Nam, Byung Lan Lee

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Conclusion. Our findings suggest that the aging process induces changes in the phenotype of olfactory supporting cells in the rat. Objective. To investigate age-related changes in the expression of astroglial intermediate filament proteins in the olfactory supporting cells of the rat. Material and methods. The expression of nestin and glial fibrillary acidic protein (GFAP) in the olfactory epithelium (OE) of young (3 months) and aged (25 months) Sprague-Dawley rats was compared using Western blotting and immunohistochemistry. Results. Western blot analysis showed nestin expression only in the young OE, whereas GFAP was detected only in the aged OE. Immunohistochemistry showed that GFAP was localized in the olfactory supporting cells of the aged OE, with regional differences.

Original languageEnglish
Pages (from-to)883-887
Number of pages5
JournalActa Oto-Laryngologica
Volume125
Issue number8
DOIs
StatePublished - 2005

Keywords

  • Aged rat
  • Glial fibrillary acidic protein
  • Nestin
  • Olfactory epithelium
  • Supporting cell

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