TY - JOUR
T1 - Gram bean extract-mediated synthesis of Fe3O4 nanoparticles for tuning the magneto-structural properties that influence the hyperthermia performance
AU - Koli, Rohit R.
AU - Phadatare, Manisha R.
AU - Sinha, Bhavesh B.
AU - Sakate, Deepak M.
AU - Ghule, Anil V.
AU - Ghodake, Gajanan S.
AU - Deshpande, Nishad G.
AU - Fulari, Vijay J.
N1 - Publisher Copyright:
© 2018 Taiwan Institute of Chemical Engineers
PY - 2019/2
Y1 - 2019/2
N2 - A green synthesis of biocompatible magnetite (Fe3O4) nanoparticles (MNPs) using a combination of urea (U) and gram-bean extract (GBE, Cicer arietinum L.) is reported. The particle size of ∼13 nm and highly stable magnetite phase is observed for GBE-U mediated MNPs. On the other hand, the MNPs synthesized using either U or GBE shows larger particle size and uneven size distribution. Interestingly, the sample with particle size ∼13 nm shows optimum heat generation capacity (measured in specific absorption rate, i.e., SAR) near to the therapeutic temperature (43 °C) with least-variance. To investigate the influence of various factors such as variation in MNPs weight concentration (Wt), applied alternating magnetic field (AMF), saturation magnetization (Ms), magnetization rate (Rm), etc. on SAR, a multiple linear regression model (MLRM) is used. The study reveals a positive correlation of SAR with Rm and AMF values while the negative correlation with Ms and Wt. Ultimately, the present green synthesis is the affordable approach for preparing stable and tiny MNPs. Moreover, MLRM is found to be a useful theoretical tool for understanding the influence of MNPs on hyperthermia performance.
AB - A green synthesis of biocompatible magnetite (Fe3O4) nanoparticles (MNPs) using a combination of urea (U) and gram-bean extract (GBE, Cicer arietinum L.) is reported. The particle size of ∼13 nm and highly stable magnetite phase is observed for GBE-U mediated MNPs. On the other hand, the MNPs synthesized using either U or GBE shows larger particle size and uneven size distribution. Interestingly, the sample with particle size ∼13 nm shows optimum heat generation capacity (measured in specific absorption rate, i.e., SAR) near to the therapeutic temperature (43 °C) with least-variance. To investigate the influence of various factors such as variation in MNPs weight concentration (Wt), applied alternating magnetic field (AMF), saturation magnetization (Ms), magnetization rate (Rm), etc. on SAR, a multiple linear regression model (MLRM) is used. The study reveals a positive correlation of SAR with Rm and AMF values while the negative correlation with Ms and Wt. Ultimately, the present green synthesis is the affordable approach for preparing stable and tiny MNPs. Moreover, MLRM is found to be a useful theoretical tool for understanding the influence of MNPs on hyperthermia performance.
KW - Biosynthesis
KW - Hyperthermia
KW - Iron oxide nanoparticles
KW - Pectin
KW - Regression model
UR - http://www.scopus.com/inward/record.url?scp=85052190854&partnerID=8YFLogxK
U2 - 10.1016/j.jtice.2018.07.039
DO - 10.1016/j.jtice.2018.07.039
M3 - Article
AN - SCOPUS:85052190854
SN - 1876-1070
VL - 95
SP - 357
EP - 368
JO - Journal of the Taiwan Institute of Chemical Engineers
JF - Journal of the Taiwan Institute of Chemical Engineers
ER -