Gram bean extract-mediated synthesis of Fe3O4 nanoparticles for tuning the magneto-structural properties that influence the hyperthermia performance

Rohit R. Koli, Manisha R. Phadatare, Bhavesh B. Sinha, Deepak M. Sakate, Anil V. Ghule, Gajanan S. Ghodake, Nishad G. Deshpande, Vijay J. Fulari

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A green synthesis of biocompatible magnetite (Fe3O4) nanoparticles (MNPs) using a combination of urea (U) and gram-bean extract (GBE, Cicer arietinum L.) is reported. The particle size of ∼13 nm and highly stable magnetite phase is observed for GBE-U mediated MNPs. On the other hand, the MNPs synthesized using either U or GBE shows larger particle size and uneven size distribution. Interestingly, the sample with particle size ∼13 nm shows optimum heat generation capacity (measured in specific absorption rate, i.e., SAR) near to the therapeutic temperature (43 °C) with least-variance. To investigate the influence of various factors such as variation in MNPs weight concentration (Wt), applied alternating magnetic field (AMF), saturation magnetization (Ms), magnetization rate (Rm), etc. on SAR, a multiple linear regression model (MLRM) is used. The study reveals a positive correlation of SAR with Rm and AMF values while the negative correlation with Ms and Wt. Ultimately, the present green synthesis is the affordable approach for preparing stable and tiny MNPs. Moreover, MLRM is found to be a useful theoretical tool for understanding the influence of MNPs on hyperthermia performance.

Original languageEnglish
Pages (from-to)357-368
Number of pages12
JournalJournal of the Taiwan Institute of Chemical Engineers
Volume95
DOIs
StatePublished - Feb 2019

Keywords

  • Biosynthesis
  • Hyperthermia
  • Iron oxide nanoparticles
  • Pectin
  • Regression model

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