Heat stress response of male germ cells

Byunghyuk Kim, Kyosun Park, Kunsoo Rhee

Research output: Contribution to journalReview articlepeer-review

122 Scopus citations

Abstract

The vast majority of mammalian testes are located outside the body cavity for proper thermoregulation. Heat has an adverse effect on mammalian spermatogenesis and eventually leads to sub- or infertility. Recent studies have provided insights into the molecular response of male germ cells to high temperatures. Here, we review the effects of heat on male germ cells and discuss the mechanisms underlying germ cell loss and impairment. We also discuss the role of translational control in male germ cells as a potential protective mechanism against heat-induced germ cell apoptosis.

Original languageEnglish
Pages (from-to)2623-2636
Number of pages14
JournalCellular and Molecular Life Sciences
Volume70
Issue number15
DOIs
StatePublished - Aug 2013

Keywords

  • DNA damage
  • Germ cell apoptosis
  • Heat stress
  • Hyperthermia
  • Infertility
  • Spermatogenesis
  • Stress granules

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