Helicobacter pylori infection and histological changes in siblings of young gastric cancer patients

Ji Hyung Nam, Il Ju Choi, Soo Jeong Cho, Chan Gyoo Kim, Jong Yeul Lee, Su Youn Nam, Sook Ryun Park, Myeong Cherl Kook, Byung Ho Nam, Young Woo Kim

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Background and Aim: Helicobacter pylori infection is a risk factor for gastric cancer. We evaluated whether H. pylori infection and premalignant histological changes are more prevalent in siblings of young gastric cancer patients. Methods: Young (age≤40) gastric cancer patients (n=185), their young siblings (n=130), and young control participants (n=287) were recruited. H. pylori infection and histological changes were assessed using the updated Sydney system in biopsy specimens from three regions. We analyzed the association of H. pylori infection and histological changes with gastric cancer using logistic regression analysis. Results: The H. pylori infection rate was significantly higher in young cancer patients than their siblings (odds ratio [OR]=2.42, P=0.001) or control participants (OR=3.60, P<0.001). In H. pylori-infected subjects, corpus gastritis and premalignant changes of the corpus lesser curvature (LCv) were also more prevalent in patients than in siblings or controls. In terms of the antrum, intestinal metaplasia was more prevalent in H. pylori-infected patients than in siblings or controls, while atrophy was not affected. Siblings also had a higher H. pylori infection rate (OR=1.60, P=0.046) and higher prevalence of intestinal metaplasia at the corpus LCv (OR=2.88, P=0.027) than control participants. Conclusions: Even in young adults, H. pylori infection is a risk factor for gastric cancer. Young adults with histological findings including corpus predominant gastritis, corpus atrophy, or intestinal metaplasia are at increased risk. Since young siblings share risk factors, screening and treatment should be considered for these family members.

Original languageEnglish
Pages (from-to)1157-1163
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume26
Issue number7
DOIs
StatePublished - Jul 2011

Keywords

  • Gastric cancer
  • Helicobacter pylori
  • Risk
  • Sibling
  • Young adult

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