Abstract
A nanohybrid, consisting of layered aluminosilicate as a host material and itraconazole as a guest molecule, was successfully synthesized through the interfacial intercalation reaction across the boundary between water and water-immiscible liquid at the various pH. According to the powder X-ray diffraction pattern, the basal spacing of the intraconazole-layered aluminosilicate nanohybrid increased from 14.7 to 22.7 Å depending on the pH of the aqueous suspension. The total amounts of itraconazole in the hybrids were determined to be 2.3∼25.4 wt% by HPLC analysis. The in vivo pharmacokinetics study was performed in rats in order to compare the absorptions of itraconazole for the itraconazole-layered aluminosilicate nanohybrid and a commercial product, Sporanox®. The pharmacokinetic data for the nanohybrid and Sporanox® showed that the mean area under the plasma concentration-time curve (AUC, 2477±898 ng·hr/mL and 2630±953 ng·hr/mL, respectively) and maximum concentration (Cmax, 225.4±77.4 ng·hr/mL and 223.6±51.9 ng·hr/mL, respectively), were within the bioequivalence (BE) range. Therefore, we concluded that this drug-layered aluminosilicate nanohybrid system has a great potential for its application in formulation of poorly soluble drugs.
Original language | English |
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Pages (from-to) | 7331-7336 |
Number of pages | 6 |
Journal | Journal of Nanoscience and Nanotechnology |
Volume | 13 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2013 |
Keywords
- Itraconazole
- Layered aluminosilicate
- Nanohybrid
- Pharmacokinetics