Heterostructured layered aluminosilicate-itraconazole nanohybrid for drug delivery system

Jae Hun Yang, Hyun Jung, Su Yeon Kim, Chul Hyun Yo, Jin Ho Choy

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A nanohybrid, consisting of layered aluminosilicate as a host material and itraconazole as a guest molecule, was successfully synthesized through the interfacial intercalation reaction across the boundary between water and water-immiscible liquid at the various pH. According to the powder X-ray diffraction pattern, the basal spacing of the intraconazole-layered aluminosilicate nanohybrid increased from 14.7 to 22.7 Å depending on the pH of the aqueous suspension. The total amounts of itraconazole in the hybrids were determined to be 2.3∼25.4 wt% by HPLC analysis. The in vivo pharmacokinetics study was performed in rats in order to compare the absorptions of itraconazole for the itraconazole-layered aluminosilicate nanohybrid and a commercial product, Sporanox®. The pharmacokinetic data for the nanohybrid and Sporanox® showed that the mean area under the plasma concentration-time curve (AUC, 2477±898 ng·hr/mL and 2630±953 ng·hr/mL, respectively) and maximum concentration (Cmax, 225.4±77.4 ng·hr/mL and 223.6±51.9 ng·hr/mL, respectively), were within the bioequivalence (BE) range. Therefore, we concluded that this drug-layered aluminosilicate nanohybrid system has a great potential for its application in formulation of poorly soluble drugs.

Original languageEnglish
Pages (from-to)7331-7336
Number of pages6
JournalJournal of Nanoscience and Nanotechnology
Volume13
Issue number11
DOIs
StatePublished - Nov 2013

Keywords

  • Itraconazole
  • Layered aluminosilicate
  • Nanohybrid
  • Pharmacokinetics

Fingerprint

Dive into the research topics of 'Heterostructured layered aluminosilicate-itraconazole nanohybrid for drug delivery system'. Together they form a unique fingerprint.

Cite this