TY - JOUR
T1 - Hierarchical dense Ni−Co layered double hydroxide supported carbon nanofibers for the electrochemical determination of metronidazole in biological samples
AU - Vilian, A. T.Ezhil
AU - Ranjith, Kugalur Shanmugam
AU - Lee, Sang Jin
AU - Umapathi, Reddicherla
AU - Hwang, Seung Kyu
AU - Oh, Cheol Woo
AU - Huh, Yun Suk
AU - Han, Young Kyu
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/9/10
Y1 - 2020/9/10
N2 - Scientific research reports have shown that long-term use of chemical and biological drugs such as Metronidazole (MNZ) can lead to certain human health issues due to its genotoxic, genotypic, carcinogenic and mutagenic type side effects in the biological samples. Therefore, the rapid exploration and rational design of electrocatalyst materials, reliable electrochemical techniques, and essential strategies to fabricate novel electrochemical sensing devices for the detection of drugs in the biological samples are of utmost interest. Herein, we developed a facile strategy to fabricate a novel electrode material consisting of conductive hierarchical dense nickel-cobalt layered double hydroxide material grown on electrospun carbon nanofibers (CNF–NiCo-LDH), which was synthesized via a simple hydrothermal method. Because of their hierarchical dense unique interconnected architecture, the CNF–NiCo-LDH deposited onto a glassy carbon electrode (GCE) exhibited improved electrocatalytic response toward metronidazole (MNZ). The fabricated electrode delivered a higher cathodic peak current for MNZ at a low peak potential of −0.54 V in the presence of 20 μM MNZ in 0.05 M phosphate-buffered solution ((PBS; pH 7). The fabricated electrode showed a wide linear response for the reduction of MNZ at concentrations from 3 to 57 nM, an extremely lower detection limit (LOD) of 0.13 nM, and a high sensitivity of 1.294 μA nM−1 cm−2. The developed electrode also showed interference-free sensing performance and excellent long-term stability. Because of its electrochemical performance, the CNF–NiCo-LDH-GCE provides a simple, fast, and effective electrochemical sensor for the detection of MNZ at the ultra-trace level in industrial and pharmaceutical applications.
AB - Scientific research reports have shown that long-term use of chemical and biological drugs such as Metronidazole (MNZ) can lead to certain human health issues due to its genotoxic, genotypic, carcinogenic and mutagenic type side effects in the biological samples. Therefore, the rapid exploration and rational design of electrocatalyst materials, reliable electrochemical techniques, and essential strategies to fabricate novel electrochemical sensing devices for the detection of drugs in the biological samples are of utmost interest. Herein, we developed a facile strategy to fabricate a novel electrode material consisting of conductive hierarchical dense nickel-cobalt layered double hydroxide material grown on electrospun carbon nanofibers (CNF–NiCo-LDH), which was synthesized via a simple hydrothermal method. Because of their hierarchical dense unique interconnected architecture, the CNF–NiCo-LDH deposited onto a glassy carbon electrode (GCE) exhibited improved electrocatalytic response toward metronidazole (MNZ). The fabricated electrode delivered a higher cathodic peak current for MNZ at a low peak potential of −0.54 V in the presence of 20 μM MNZ in 0.05 M phosphate-buffered solution ((PBS; pH 7). The fabricated electrode showed a wide linear response for the reduction of MNZ at concentrations from 3 to 57 nM, an extremely lower detection limit (LOD) of 0.13 nM, and a high sensitivity of 1.294 μA nM−1 cm−2. The developed electrode also showed interference-free sensing performance and excellent long-term stability. Because of its electrochemical performance, the CNF–NiCo-LDH-GCE provides a simple, fast, and effective electrochemical sensor for the detection of MNZ at the ultra-trace level in industrial and pharmaceutical applications.
KW - Carbon nanofibers
KW - Differential pulse voltammetry
KW - Electrochemical sensor
KW - Layered double hydroxide
KW - Metronidazole
UR - http://www.scopus.com/inward/record.url?scp=85088015459&partnerID=8YFLogxK
U2 - 10.1016/j.electacta.2020.136723
DO - 10.1016/j.electacta.2020.136723
M3 - Article
AN - SCOPUS:85088015459
SN - 0013-4686
VL - 354
JO - Electrochimica Acta
JF - Electrochimica Acta
M1 - 136723
ER -