TY - JOUR
T1 - Highly sensitive and selective detection of dopamine using atomic layer deposited HfO2 ultra-thin films
AU - Abraham, Daniel Arulraj
AU - Li, Ai Dong
AU - Sanmugam, Anandhavelu
AU - Wadaan, Mohammad Ahmad
AU - Baabbad, Almohannad
AU - Kanagaraj, Kuppusamy
AU - Karuppasamy, K.
AU - Maiyalagan, T.
AU - Kim, Hyun Seok
AU - Vikraman, Dhanasekaran
N1 - Publisher Copyright:
© 2024 Elsevier Ltd
PY - 2024/9/1
Y1 - 2024/9/1
N2 - The development of non-enzymatic and binder-free biosensors plays a vital role, and it possesses main benefits for effective biomolecule recognition with high sensitivity and preferred selectivity. Herein, an atomic layer deposition (ALD) was employed to develop the hafnium oxide (HfO2) nanofilm on silicon (Si) for fabricating binder-free selective and sensitive determination of the non-enzymatic electrochemical dopamine sensor. The prepared HfO2 nanofilm selectively acted as a local dopamine binding site because of the hydrophobic-hydrophobic interaction between fabricated film and dopamine, electrostatic attraction between negatively charged hydroxyl group on film surfaces, and positively charged amino group of dopamine. The developed insufficient oxygen vacancies on the HfO2 could have behaved as a charge-trapping site for better sensing properties. The developed sensor demonstrated excellent realization in sensing dopamine with a very low detection limit (0.4 pM) and swift response time of 3s which is quite precise compared with various reported literature. The fabricated HfO2/Si electrode sensor has exhibited high sensitivity, stability, and repeatability. The selectivity of dopamine sensors was at least three orders greater than other interfering biomolecules. This work proposes the essential track for the practical realization of dopamine detection in human serum and biomedical applications.
AB - The development of non-enzymatic and binder-free biosensors plays a vital role, and it possesses main benefits for effective biomolecule recognition with high sensitivity and preferred selectivity. Herein, an atomic layer deposition (ALD) was employed to develop the hafnium oxide (HfO2) nanofilm on silicon (Si) for fabricating binder-free selective and sensitive determination of the non-enzymatic electrochemical dopamine sensor. The prepared HfO2 nanofilm selectively acted as a local dopamine binding site because of the hydrophobic-hydrophobic interaction between fabricated film and dopamine, electrostatic attraction between negatively charged hydroxyl group on film surfaces, and positively charged amino group of dopamine. The developed insufficient oxygen vacancies on the HfO2 could have behaved as a charge-trapping site for better sensing properties. The developed sensor demonstrated excellent realization in sensing dopamine with a very low detection limit (0.4 pM) and swift response time of 3s which is quite precise compared with various reported literature. The fabricated HfO2/Si electrode sensor has exhibited high sensitivity, stability, and repeatability. The selectivity of dopamine sensors was at least three orders greater than other interfering biomolecules. This work proposes the essential track for the practical realization of dopamine detection in human serum and biomedical applications.
KW - ALD
KW - Biosensor
KW - Dopamine
KW - Electrochemical sensor
KW - HfO
KW - Thin film
UR - http://www.scopus.com/inward/record.url?scp=85196046682&partnerID=8YFLogxK
U2 - 10.1016/j.electacta.2024.144574
DO - 10.1016/j.electacta.2024.144574
M3 - Article
AN - SCOPUS:85196046682
SN - 0013-4686
VL - 497
JO - Electrochimica Acta
JF - Electrochimica Acta
M1 - 144574
ER -