TY - JOUR
T1 - Horizons of nanotechnology applications in female specific cancers
AU - Rajitha, Balney
AU - Malla, Rama Rao
AU - Vadde, Ramakrishna
AU - Kasa, Prameswari
AU - Prasad, Ganji Lakshmi Vara
AU - Farran, Batoul
AU - Kumari, Seema
AU - Pavitra, Eluri
AU - Kamal, Mohammad Amjad
AU - Raju, Ganji Seeta Rama
AU - Peela, Sujatha
AU - Nagaraju, Ganji Purnachandra
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2021/2
Y1 - 2021/2
N2 - Female-specific cancers are the most common cancers in women worldwide. Early detection methods remain unavailable for most of these cancers, signifying that most of them are diagnosed at later stages. Furthermore, current treatment options for most female-specific cancers are surgery, radiation and chemotherapy. Although important milestones in molecularly targeted approaches have been achieved lately, current therapeutic strategies for female-specific cancers remain limited, ineffective and plagued by the emergence of chemoresistance, which aggravates prognosis. Recently, the application of nanotechnology to the medical field has allowed the development of novel nano-based approaches for the management and treatment of cancers, including female-specific cancers. These approaches promise to improve patient survival rates by reducing side effects, enabling selective delivery of drugs to tumor tissues and enhancing the uptake of therapeutic compounds, thus increasing anti-tumor activity. In this review, we focus on the application of nano-based technologies to the design of novel and innovative diagnostic and therapeutic strategies in the context of female-specific cancers, highlighting their potential uses and limitations.
AB - Female-specific cancers are the most common cancers in women worldwide. Early detection methods remain unavailable for most of these cancers, signifying that most of them are diagnosed at later stages. Furthermore, current treatment options for most female-specific cancers are surgery, radiation and chemotherapy. Although important milestones in molecularly targeted approaches have been achieved lately, current therapeutic strategies for female-specific cancers remain limited, ineffective and plagued by the emergence of chemoresistance, which aggravates prognosis. Recently, the application of nanotechnology to the medical field has allowed the development of novel nano-based approaches for the management and treatment of cancers, including female-specific cancers. These approaches promise to improve patient survival rates by reducing side effects, enabling selective delivery of drugs to tumor tissues and enhancing the uptake of therapeutic compounds, thus increasing anti-tumor activity. In this review, we focus on the application of nano-based technologies to the design of novel and innovative diagnostic and therapeutic strategies in the context of female-specific cancers, highlighting their potential uses and limitations.
KW - Breast cancer
KW - Cervical cancer
KW - Female specific cancers
KW - Nanotechnology
KW - Ovarian cancer
UR - http://www.scopus.com/inward/record.url?scp=85068823337&partnerID=8YFLogxK
U2 - 10.1016/j.semcancer.2019.07.005
DO - 10.1016/j.semcancer.2019.07.005
M3 - Review article
C2 - 31301361
AN - SCOPUS:85068823337
SN - 1044-579X
VL - 69
SP - 376
EP - 390
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
ER -