HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer

Ganji Seeta Rama Raju; Eluri Pavitra; Sai Samyuktha Bandaru; Ganji Lakshmi Varaprasad; Ganji Purnachandra Nagaraju; Rama Rao Malla; Yun Suk Huh; Young Kyu Han

doi:10.1186/s12943-023-01765-3

HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer

Ganji Seeta Rama Raju, Eluri Pavitra, Sai Samyuktha Bandaru, Ganji Lakshmi Varaprasad, Ganji Purnachandra Nagaraju, Rama Rao Malla, Yun Suk Huh, Young Kyu Han

Department of Energy and Materials Engineering

Research output: Contribution to journal › Review article › peer-review

58 Scopus citations

Abstract

HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and controls various oncogenic cellular and signaling mechanisms including metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by a variety of transcriptional and epigenetic mechanisms. In this review, we describe the regulatory mechanisms that govern HOTAIR expression during cancer development and explore how HOTAIR drives BC development, metastasis, and drug resistance. In the final section of this review, we focus on the role of HOTAIR in BC management, therapeutic treatment, and prognosis, highlighting its potential therapeutic applications.

Original language	English
Article number	65
Journal	Molecular Cancer
Volume	22
Issue number	1
DOIs	https://doi.org/10.1186/s12943-023-01765-3
State	Published - Dec 2023

Keywords

Breast cancer
Drug resistance
HOTAIR
Metastasis
Prognosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12943-023-01765-3

Cite this

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title = "HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer",

abstract = "HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and controls various oncogenic cellular and signaling mechanisms including metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by a variety of transcriptional and epigenetic mechanisms. In this review, we describe the regulatory mechanisms that govern HOTAIR expression during cancer development and explore how HOTAIR drives BC development, metastasis, and drug resistance. In the final section of this review, we focus on the role of HOTAIR in BC management, therapeutic treatment, and prognosis, highlighting its potential therapeutic applications.",

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doi = "10.1186/s12943-023-01765-3",

language = "English",

volume = "22",

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T2 - a potential metastatic, drug-resistant and prognostic regulator of breast cancer

AU - Raju, Ganji Seeta Rama

AU - Pavitra, Eluri

AU - Bandaru, Sai Samyuktha

AU - Varaprasad, Ganji Lakshmi

AU - Nagaraju, Ganji Purnachandra

AU - Malla, Rama Rao

AU - Huh, Yun Suk

AU - Han, Young Kyu

PY - 2023/12

Y1 - 2023/12

N2 - HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and controls various oncogenic cellular and signaling mechanisms including metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by a variety of transcriptional and epigenetic mechanisms. In this review, we describe the regulatory mechanisms that govern HOTAIR expression during cancer development and explore how HOTAIR drives BC development, metastasis, and drug resistance. In the final section of this review, we focus on the role of HOTAIR in BC management, therapeutic treatment, and prognosis, highlighting its potential therapeutic applications.

AB - HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and controls various oncogenic cellular and signaling mechanisms including metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by a variety of transcriptional and epigenetic mechanisms. In this review, we describe the regulatory mechanisms that govern HOTAIR expression during cancer development and explore how HOTAIR drives BC development, metastasis, and drug resistance. In the final section of this review, we focus on the role of HOTAIR in BC management, therapeutic treatment, and prognosis, highlighting its potential therapeutic applications.

KW - Breast cancer

KW - Drug resistance

KW - HOTAIR

KW - Metastasis

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=85151316327&partnerID=8YFLogxK

U2 - 10.1186/s12943-023-01765-3

DO - 10.1186/s12943-023-01765-3

M3 - Review article

C2 - 36997931

AN - SCOPUS:85151316327

SN - 1476-4598

VL - 22

JO - Molecular Cancer

JF - Molecular Cancer

IS - 1

M1 - 65

ER -

HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer

Abstract

Keywords

UN SDGs

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