TY - JOUR
T1 - Human Cancer Cell Line Based Approach of 1,3,4-thiadiazole and its Fused Ring
T2 - A Comprehensive Review
AU - Raj, Vinit
AU - Rai, Amit
AU - Saha, Sudipta
N1 - Publisher Copyright:
© 2017 Bentham Science Publishers.
PY - 2017/4
Y1 - 2017/4
N2 - The chemistry of heterocyclic containing, 1,3,4-thiadiazole has been an interesting field of study from ancient years. Subsequently, 1,3,4-thiadiazole nucleus constitutes a significant class of compounds for new drug development. Recently, various 1,3,4-thiadiazole derivatives synthesized and evaluated their biological activities including antimicrobial, antituberculosis, antioxidant, anti-inflammatory, anticonvulsants, antidepressant and anxiolytic, antihypertensive, anticancer and antifungal activity. The search for anticancer compounds with more selective activities and lower side effect continues to be an active area of argument examination in medicinal chemistry. This review elaborately described the medicinal chemistry, their structural activity relationship, and anticancer properties with respect to human cell line based approach related to synthesized 1,3,4-thiadiazole derivatives.
AB - The chemistry of heterocyclic containing, 1,3,4-thiadiazole has been an interesting field of study from ancient years. Subsequently, 1,3,4-thiadiazole nucleus constitutes a significant class of compounds for new drug development. Recently, various 1,3,4-thiadiazole derivatives synthesized and evaluated their biological activities including antimicrobial, antituberculosis, antioxidant, anti-inflammatory, anticonvulsants, antidepressant and anxiolytic, antihypertensive, anticancer and antifungal activity. The search for anticancer compounds with more selective activities and lower side effect continues to be an active area of argument examination in medicinal chemistry. This review elaborately described the medicinal chemistry, their structural activity relationship, and anticancer properties with respect to human cell line based approach related to synthesized 1,3,4-thiadiazole derivatives.
KW - 1,3,4-thiadiazole
KW - Cancer cell lines
KW - Mechanism of action
KW - Structure-activity-relationship
UR - https://www.scopus.com/pages/publications/85027527755
U2 - 10.2174/1871520616666161013150151
DO - 10.2174/1871520616666161013150151
M3 - Review article
C2 - 27745547
AN - SCOPUS:85027527755
SN - 1871-5206
VL - 17
SP - 500
EP - 523
JO - Anti-Cancer Agents in Medicinal Chemistry
JF - Anti-Cancer Agents in Medicinal Chemistry
IS - 4
ER -
