Human disease-related long noncoding RNAs: Impact of ginsenosides

Siyeon Jang, Hyeonjin Lee, Hyeon Woo Kim, Minjae Baek, Sanghyun Jung, Sun Jung Kim

Research output: Contribution to journalReview articlepeer-review

Abstract

Ginsenosides in ginseng are known for their potential health benefits, including antioxidant properties and their potential to exhibit anticancer effects. Besides a various range of coding genes, ginsenosides impose their efficacy by targeting noncoding RNAs. Long noncoding RNA (lncRNA) has gained significant attention from both basic and clinical oncology fields due to its involvement in various cancer cell activities such as proliferation, apoptosis, metastasis, and autophagy. These events can be achieved either by lncRNA alone or in association with microRNAs or proteins. This review aims to summarize the diverse activities of lncRNAs that are regulated by ginsenosides, focusing on their role in regulating target genes through signaling pathways in human diseases. We highlight the results of studies on the expression profiles of lncRNAs induced by ginsenosides in efforts to inhibit cancer cell proliferation. Finally, we discuss the potential and challenges of utilizing lncRNAs as diagnostic markers for disease treatment.

Original languageEnglish
Pages (from-to)347-353
Number of pages7
JournalJournal of Ginseng Research
Volume48
Issue number4
DOIs
StatePublished - Jul 2024

Keywords

  • Cancer
  • Diagnostic markers
  • Ginsenosides
  • Long noncoding RNAs

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