Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with transient forebrain ischemia

Kon Chu, Manho Kim, Sang Wuk Jeong, Seung U. Kim, Byung Woo Yoon

Research output: Contribution to journalArticlepeer-review

181 Scopus citations

Abstract

Intraparenchymally transplanted rodent-origin neural and human-origin mesenchymal stem cells migrate and differentiate in neurological diseases. By intravenously injecting human neural stem cells, we showed that transplanted human neural stem cells migrate to the damaged hippocampus, proliferate and differentiate into mature neurons and astrocytes in the adult rat brain with transient forebrain ischemia. We also demonstrated the migratory course of implanted human neural stem cells after intravenous injection. Our findings show that transplanted human neural stem cells differentiate into mature neurons to replace lost neural cells in the adult hippocampus with human-rat neural chimeras.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalNeuroscience Letters
Volume343
Issue number2
DOIs
StatePublished - 5 Jun 2003

Keywords

  • Chimera
  • Differentiation
  • Global ischemia
  • Hippocampus
  • Human neural stem cell
  • Intravenous
  • Migration
  • Radial glia
  • Rat
  • Transplantation

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