Hybrid mouse diversity panel: A panel of inbred mouse strains suitable for analysis of complex genetic traits

Anatole Ghazalpour; Christoph D. Rau; Charles R. Farber; Brian J. Bennett; Luz D. Orozco; Atila Van Nas; Calvin Pan; Hooman Allayee; Simon W. Beaven; Mete Civelek; Richard C. Davis; Thomas A. Drake; Rick A. Friedman; Nick Furlotte; Simon T. Hui; J. David Jentsch; Emrah Kostem; Hyun Min Kang; Eun Yong Kang; Jong Wha Joo; Vyacheslav A. Korshunov; Rick E. Laughlin; Lisa J. Martin; Jeffrey D. Ohmen; Brian W. Parks; Matteo Pellegrini; Karen Reue; Desmond J. Smith; Sotirios Tetradis; Jessica Wang; Yibin Wang; James N. Weiss; Todd Kirchgessner; Peter S. Gargalovic; Eleazar Eskin; Aldons J. Lusis; Renée C. LeBoeuf

doi:10.1007/s00335-012-9411-5

Hybrid mouse diversity panel: A panel of inbred mouse strains suitable for analysis of complex genetic traits

Anatole Ghazalpour
, Christoph D. Rau
, Charles R. Farber
, Brian J. Bennett
, Luz D. Orozco
, Atila Van Nas
, Calvin Pan
, Hooman Allayee
, Simon W. Beaven
, Mete Civelek
, Richard C. Davis
, Thomas A. Drake
, Rick A. Friedman
, Nick Furlotte
, Simon T. Hui
, J. David Jentsch
, Emrah Kostem
, Hyun Min Kang
, Eun Yong Kang
, Jong Wha Joo

Vyacheslav A. Korshunov, Rick E. Laughlin, Lisa J. Martin, Jeffrey D. Ohmen, Brian W. Parks, Matteo Pellegrini, Karen Reue, Desmond J. Smith, Sotirios Tetradis, Jessica Wang, Yibin Wang, James N. Weiss, Todd Kirchgessner, Peter S. Gargalovic, Eleazar Eskin, Aldons J. Lusis, Renée C. LeBoeuf

Department of Computer Science and Artificial Intelligence

University of California at Los Angeles
University of Virginia
University of North Carolina at Chapel Hill
University of Southern California
House Research Institute
University of Michigan, Ann Arbor
University of Rochester
House Research Institute
Bristol-Myers Squibb
University of Washington

Research output: Contribution to journal › Review article › peer-review

114 Scopus citations

Abstract

We have developed an association-based approach using classical inbred strains of mice in which we correct for population structure, which is very extensive in mice, using an efficient mixed-model algorithm. Our approach includes inbred parental strains as well as recombinant inbred strains in order to capture loci with effect sizes typical of complex traits in mice (in the range of 5 % of total trait variance). Over the last few years, we have typed the hybrid mouse diversity panel (HMDP) strains for a variety of clinical traits as well as intermediate phenotypes and have shown that the HMDP has sufficient power to map genes for highly complex traits with resolution that is in most cases less than a megabase. In this essay, we review our experience with the HMDP, describe various ongoing projects, and discuss how the HMDP may fit into the larger picture of common diseases and different approaches.

Original language	English
Pages (from-to)	680-692
Number of pages	13
Journal	Mammalian Genome
Volume	23
Issue number	9-10
DOIs	https://doi.org/10.1007/s00335-012-9411-5
State	Published - Oct 2012

Access to Document

10.1007/s00335-012-9411-5

Cite this

Ghazalpour, A., Rau, C. D., Farber, C. R., Bennett, B. J., Orozco, L. D., Van Nas, A., Pan, C., Allayee, H., Beaven, S. W., Civelek, M., Davis, R. C., Drake, T. A., Friedman, R. A., Furlotte, N., Hui, S. T., Jentsch, J. D., Kostem, E., Kang, H. M., Kang, E. Y., ... LeBoeuf, R. C. (2012). Hybrid mouse diversity panel: A panel of inbred mouse strains suitable for analysis of complex genetic traits. Mammalian Genome, 23(9-10), 680-692. https://doi.org/10.1007/s00335-012-9411-5

@article{40deca0d689b44c2af1062a4c422ca0d,

title = "Hybrid mouse diversity panel: A panel of inbred mouse strains suitable for analysis of complex genetic traits",

abstract = "We have developed an association-based approach using classical inbred strains of mice in which we correct for population structure, which is very extensive in mice, using an efficient mixed-model algorithm. Our approach includes inbred parental strains as well as recombinant inbred strains in order to capture loci with effect sizes typical of complex traits in mice (in the range of 5 \% of total trait variance). Over the last few years, we have typed the hybrid mouse diversity panel (HMDP) strains for a variety of clinical traits as well as intermediate phenotypes and have shown that the HMDP has sufficient power to map genes for highly complex traits with resolution that is in most cases less than a megabase. In this essay, we review our experience with the HMDP, describe various ongoing projects, and discuss how the HMDP may fit into the larger picture of common diseases and different approaches.",

author = "Anatole Ghazalpour and Rau, \{Christoph D.\} and Farber, \{Charles R.\} and Bennett, \{Brian J.\} and Orozco, \{Luz D.\} and \{Van Nas\}, Atila and Calvin Pan and Hooman Allayee and Beaven, \{Simon W.\} and Mete Civelek and Davis, \{Richard C.\} and Drake, \{Thomas A.\} and Friedman, \{Rick A.\} and Nick Furlotte and Hui, \{Simon T.\} and Jentsch, \{J. David\} and Emrah Kostem and Kang, \{Hyun Min\} and Kang, \{Eun Yong\} and Joo, \{Jong Wha\} and Korshunov, \{Vyacheslav A.\} and Laughlin, \{Rick E.\} and Martin, \{Lisa J.\} and Ohmen, \{Jeffrey D.\} and Parks, \{Brian W.\} and Matteo Pellegrini and Karen Reue and Smith, \{Desmond J.\} and Sotirios Tetradis and Jessica Wang and Yibin Wang and Weiss, \{James N.\} and Todd Kirchgessner and Gargalovic, \{Peter S.\} and Eleazar Eskin and Lusis, \{Aldons J.\} and LeBoeuf, \{Ren{\'e}e C.\}",

year = "2012",

month = oct,

doi = "10.1007/s00335-012-9411-5",

language = "English",

volume = "23",

pages = "680--692",

journal = "Mammalian Genome",

issn = "0938-8990",

publisher = "Springer",

number = "9-10",

}

Ghazalpour, A, Rau, CD, Farber, CR, Bennett, BJ, Orozco, LD, Van Nas, A, Pan, C, Allayee, H, Beaven, SW, Civelek, M, Davis, RC, Drake, TA, Friedman, RA, Furlotte, N, Hui, ST, Jentsch, JD, Kostem, E, Kang, HM, Kang, EY, Joo, JW, Korshunov, VA, Laughlin, RE, Martin, LJ, Ohmen, JD, Parks, BW, Pellegrini, M, Reue, K, Smith, DJ, Tetradis, S, Wang, J, Wang, Y, Weiss, JN, Kirchgessner, T, Gargalovic, PS, Eskin, E, Lusis, AJ & LeBoeuf, RC 2012, 'Hybrid mouse diversity panel: A panel of inbred mouse strains suitable for analysis of complex genetic traits', Mammalian Genome, vol. 23, no. 9-10, pp. 680-692. https://doi.org/10.1007/s00335-012-9411-5

TY - JOUR

T1 - Hybrid mouse diversity panel

T2 - A panel of inbred mouse strains suitable for analysis of complex genetic traits

AU - Ghazalpour, Anatole

AU - Rau, Christoph D.

AU - Farber, Charles R.

AU - Bennett, Brian J.

AU - Orozco, Luz D.

AU - Van Nas, Atila

AU - Pan, Calvin

AU - Allayee, Hooman

AU - Beaven, Simon W.

AU - Civelek, Mete

AU - Davis, Richard C.

AU - Drake, Thomas A.

AU - Friedman, Rick A.

AU - Furlotte, Nick

AU - Hui, Simon T.

AU - Jentsch, J. David

AU - Kostem, Emrah

AU - Kang, Hyun Min

AU - Kang, Eun Yong

AU - Joo, Jong Wha

AU - Korshunov, Vyacheslav A.

AU - Laughlin, Rick E.

AU - Martin, Lisa J.

AU - Ohmen, Jeffrey D.

AU - Parks, Brian W.

AU - Pellegrini, Matteo

AU - Reue, Karen

AU - Smith, Desmond J.

AU - Tetradis, Sotirios

AU - Wang, Jessica

AU - Wang, Yibin

AU - Weiss, James N.

AU - Kirchgessner, Todd

AU - Gargalovic, Peter S.

AU - Eskin, Eleazar

AU - Lusis, Aldons J.

AU - LeBoeuf, Renée C.

PY - 2012/10

Y1 - 2012/10

N2 - We have developed an association-based approach using classical inbred strains of mice in which we correct for population structure, which is very extensive in mice, using an efficient mixed-model algorithm. Our approach includes inbred parental strains as well as recombinant inbred strains in order to capture loci with effect sizes typical of complex traits in mice (in the range of 5 % of total trait variance). Over the last few years, we have typed the hybrid mouse diversity panel (HMDP) strains for a variety of clinical traits as well as intermediate phenotypes and have shown that the HMDP has sufficient power to map genes for highly complex traits with resolution that is in most cases less than a megabase. In this essay, we review our experience with the HMDP, describe various ongoing projects, and discuss how the HMDP may fit into the larger picture of common diseases and different approaches.

AB - We have developed an association-based approach using classical inbred strains of mice in which we correct for population structure, which is very extensive in mice, using an efficient mixed-model algorithm. Our approach includes inbred parental strains as well as recombinant inbred strains in order to capture loci with effect sizes typical of complex traits in mice (in the range of 5 % of total trait variance). Over the last few years, we have typed the hybrid mouse diversity panel (HMDP) strains for a variety of clinical traits as well as intermediate phenotypes and have shown that the HMDP has sufficient power to map genes for highly complex traits with resolution that is in most cases less than a megabase. In this essay, we review our experience with the HMDP, describe various ongoing projects, and discuss how the HMDP may fit into the larger picture of common diseases and different approaches.

UR - https://www.scopus.com/pages/publications/84867332713

U2 - 10.1007/s00335-012-9411-5

DO - 10.1007/s00335-012-9411-5

M3 - Review article

C2 - 22892838

AN - SCOPUS:84867332713

SN - 0938-8990

VL - 23

SP - 680

EP - 692

JO - Mammalian Genome

JF - Mammalian Genome

IS - 9-10

ER -

Hybrid mouse diversity panel: A panel of inbred mouse strains suitable for analysis of complex genetic traits

Abstract

Access to Document

Other files and links

Fingerprint

Cite this