TY - JOUR
T1 - Hydrolyzable tannins from the fruits of Terminalia chebula Retz and their α-glucosidase inhibitory activities
AU - Lee, Dong Young
AU - Kim, Hyun Woo
AU - Yang, Heejung
AU - Sung, Sang Hyun
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Nine hydrolyzable tannins, including three previously unknown and six artifacts, were isolated, together with thirty-nine known ones, from the fruits of Terminalia chebula Retz. (Combretaceae). They were identified as 1,2,3-tri-O-galloyl-6-O-cinnamoyl-β-D-glucose, 1,2,3,6-tetra-O-galloyl-4-O-cinnamoyl-β-D-glucose, 4-O-(2″,4″-di-O-galloyl-α-L-rhamnosyl)ellagic acid, 1′-O-methyl neochebulanin, dimethyl neochebulinate, 6′-O-methyl neochebulagate, dimethyl neochebulagate, dimethyl 4′-epi-neochebulagate, and methyl chebulagate by the spectroscopic interpretation. After evaluation for α-glucosidase inhibition of all isolated compounds, 1,2,3,6-tetra-O-galloyl-4-O-cinnamoyl-β-D-glucose and 4-O-(2″,4″-di-O-galloyl-α-L-rhamnosyl)ellagic acid showed significant inhibitory activities with IC50 values of 2.9 and 6.4 μM, respectively. In addition, inhibition kinetic studies showed that both compounds have mixed-type inhibitory activities with the inhibition constants (Ki) of 1.9 and 4.0 μM, respectively.
AB - Nine hydrolyzable tannins, including three previously unknown and six artifacts, were isolated, together with thirty-nine known ones, from the fruits of Terminalia chebula Retz. (Combretaceae). They were identified as 1,2,3-tri-O-galloyl-6-O-cinnamoyl-β-D-glucose, 1,2,3,6-tetra-O-galloyl-4-O-cinnamoyl-β-D-glucose, 4-O-(2″,4″-di-O-galloyl-α-L-rhamnosyl)ellagic acid, 1′-O-methyl neochebulanin, dimethyl neochebulinate, 6′-O-methyl neochebulagate, dimethyl neochebulagate, dimethyl 4′-epi-neochebulagate, and methyl chebulagate by the spectroscopic interpretation. After evaluation for α-glucosidase inhibition of all isolated compounds, 1,2,3,6-tetra-O-galloyl-4-O-cinnamoyl-β-D-glucose and 4-O-(2″,4″-di-O-galloyl-α-L-rhamnosyl)ellagic acid showed significant inhibitory activities with IC50 values of 2.9 and 6.4 μM, respectively. In addition, inhibition kinetic studies showed that both compounds have mixed-type inhibitory activities with the inhibition constants (Ki) of 1.9 and 4.0 μM, respectively.
KW - Combretaceae α-glucosidase
KW - Hydrolyzable tannin
KW - IC value
KW - Terminalia chebula
UR - http://www.scopus.com/inward/record.url?scp=85012941299&partnerID=8YFLogxK
U2 - 10.1016/j.phytochem.2017.02.006
DO - 10.1016/j.phytochem.2017.02.006
M3 - Article
C2 - 28213992
AN - SCOPUS:85012941299
SN - 0031-9422
VL - 137
SP - 109
EP - 116
JO - Phytochemistry
JF - Phytochemistry
ER -