Hydrolyzable tannins from the fruits of Terminalia chebula Retz and their α-glucosidase inhibitory activities

Dong Young Lee, Hyun Woo Kim, Heejung Yang, Sang Hyun Sung

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Nine hydrolyzable tannins, including three previously unknown and six artifacts, were isolated, together with thirty-nine known ones, from the fruits of Terminalia chebula Retz. (Combretaceae). They were identified as 1,2,3-tri-O-galloyl-6-O-cinnamoyl-β-D-glucose, 1,2,3,6-tetra-O-galloyl-4-O-cinnamoyl-β-D-glucose, 4-O-(2″,4″-di-O-galloyl-α-L-rhamnosyl)ellagic acid, 1′-O-methyl neochebulanin, dimethyl neochebulinate, 6′-O-methyl neochebulagate, dimethyl neochebulagate, dimethyl 4′-epi-neochebulagate, and methyl chebulagate by the spectroscopic interpretation. After evaluation for α-glucosidase inhibition of all isolated compounds, 1,2,3,6-tetra-O-galloyl-4-O-cinnamoyl-β-D-glucose and 4-O-(2″,4″-di-O-galloyl-α-L-rhamnosyl)ellagic acid showed significant inhibitory activities with IC50 values of 2.9 and 6.4 μM, respectively. In addition, inhibition kinetic studies showed that both compounds have mixed-type inhibitory activities with the inhibition constants (Ki) of 1.9 and 4.0 μM, respectively.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalPhytochemistry
Volume137
DOIs
StatePublished - 1 May 2017

Keywords

  • Combretaceae α-glucosidase
  • Hydrolyzable tannin
  • IC value
  • Terminalia chebula

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