Abstract
Background: HP0892 of H. pylori shares high structural similarity with other toxin-antitoxin (TA) system toxins. Results: RNase activity and cell toxicity of HP0892 is inhibited by HP0893 via strong protein-protein interaction. Conclusion: HP0892-HP0893 pair is a TA system with a protein-protein interaction mode similar to other TA pairs. Significance: It is highly probable that HP0892-HP0893 TA pair is involved in H. pylori virulence.
Original language | English |
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Pages (from-to) | 6004-6013 |
Number of pages | 10 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 8 |
DOIs | |
State | Published - 22 Feb 2013 |