Identification of chromosomal HP0892-HP0893 toxin-antitoxin proteins in helicobacter pylori and structural elucidation of their protein-protein interaction

Kyung Doo Han, Do Hwan Ahn, Seung A. Lee, Yu Hong Min, Ae Ran Kwon, Hee Chul Ahn, Bong Jin Lee

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background: HP0892 of H. pylori shares high structural similarity with other toxin-antitoxin (TA) system toxins. Results: RNase activity and cell toxicity of HP0892 is inhibited by HP0893 via strong protein-protein interaction. Conclusion: HP0892-HP0893 pair is a TA system with a protein-protein interaction mode similar to other TA pairs. Significance: It is highly probable that HP0892-HP0893 TA pair is involved in H. pylori virulence.

Original languageEnglish
Pages (from-to)6004-6013
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number8
DOIs
StatePublished - 22 Feb 2013

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