Identification of chromosomal HP0892-HP0893 toxin-antitoxin proteins in helicobacter pylori and structural elucidation of their protein-protein interaction

Kyung Doo Han; Do Hwan Ahn; Seung A. Lee; Yu Hong Min; Ae Ran Kwon; Hee Chul Ahn; Bong Jin Lee

doi:10.1074/jbc.M111.322784

Identification of chromosomal HP0892-HP0893 toxin-antitoxin proteins in helicobacter pylori and structural elucidation of their protein-protein interaction

Kyung Doo Han
, Do Hwan Ahn
, Seung A. Lee
, Yu Hong Min
, Ae Ran Kwon
, Hee Chul Ahn
, Bong Jin Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Background: HP0892 of H. pylori shares high structural similarity with other toxin-antitoxin (TA) system toxins. Results: RNase activity and cell toxicity of HP0892 is inhibited by HP0893 via strong protein-protein interaction. Conclusion: HP0892-HP0893 pair is a TA system with a protein-protein interaction mode similar to other TA pairs. Significance: It is highly probable that HP0892-HP0893 TA pair is involved in H. pylori virulence.

Original language	English
Pages (from-to)	6004-6013
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M111.322784
State	Published - 22 Feb 2013

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title = "Identification of chromosomal HP0892-HP0893 toxin-antitoxin proteins in helicobacter pylori and structural elucidation of their protein-protein interaction",

abstract = "Background: HP0892 of H. pylori shares high structural similarity with other toxin-antitoxin (TA) system toxins. Results: RNase activity and cell toxicity of HP0892 is inhibited by HP0893 via strong protein-protein interaction. Conclusion: HP0892-HP0893 pair is a TA system with a protein-protein interaction mode similar to other TA pairs. Significance: It is highly probable that HP0892-HP0893 TA pair is involved in H. pylori virulence.",

author = "Han, \{Kyung Doo\} and Ahn, \{Do Hwan\} and Lee, \{Seung A.\} and Min, \{Yu Hong\} and Kwon, \{Ae Ran\} and Ahn, \{Hee Chul\} and Lee, \{Bong Jin\}",

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doi = "10.1074/jbc.M111.322784",

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TY - JOUR

T1 - Identification of chromosomal HP0892-HP0893 toxin-antitoxin proteins in helicobacter pylori and structural elucidation of their protein-protein interaction

AU - Han, Kyung Doo

AU - Ahn, Do Hwan

AU - Lee, Seung A.

AU - Min, Yu Hong

AU - Kwon, Ae Ran

AU - Ahn, Hee Chul

AU - Lee, Bong Jin

PY - 2013/2/22

Y1 - 2013/2/22

N2 - Background: HP0892 of H. pylori shares high structural similarity with other toxin-antitoxin (TA) system toxins. Results: RNase activity and cell toxicity of HP0892 is inhibited by HP0893 via strong protein-protein interaction. Conclusion: HP0892-HP0893 pair is a TA system with a protein-protein interaction mode similar to other TA pairs. Significance: It is highly probable that HP0892-HP0893 TA pair is involved in H. pylori virulence.

AB - Background: HP0892 of H. pylori shares high structural similarity with other toxin-antitoxin (TA) system toxins. Results: RNase activity and cell toxicity of HP0892 is inhibited by HP0893 via strong protein-protein interaction. Conclusion: HP0892-HP0893 pair is a TA system with a protein-protein interaction mode similar to other TA pairs. Significance: It is highly probable that HP0892-HP0893 TA pair is involved in H. pylori virulence.

UR - https://www.scopus.com/pages/publications/84874333964

U2 - 10.1074/jbc.M111.322784

DO - 10.1074/jbc.M111.322784

M3 - Article

C2 - 23297406

AN - SCOPUS:84874333964

SN - 0021-9258

VL - 288

SP - 6004

EP - 6013

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 8

ER -

Identification of chromosomal HP0892-HP0893 toxin-antitoxin proteins in helicobacter pylori and structural elucidation of their protein-protein interaction

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