Imidacloprid, a neonicotinoid insecticide, potentiates adipogenesis in 3T3-L1 adipocytes

Yeonhwa Park, Yooheon Park, Younghwa Kim, Jonggun Kim, Kyong Sup Yoon, John Clark, Junsoo Lee

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

There is emerging evidence that organochlorine and organophosphorus insecticide exposure may be linked to excessive weight gain and symptoms of diabetes. However, there is a lack of knowledge for other types of insecticides with potential influence on obesity and diabetes. Thus, the purpose of this investigation was to determine the role of imidacloprid, a neonicotinoid insecticide, in lipid metabolism by use of 3T3-L1 adipocytes. Imidacloprid treatment potentiated lipid accumulation in 3T3-L1 adipocytes and significantly increased expression of a key regulator of adipocyte differentiation and key regulators of lipogenesis. These results imply the involvement of imidacloprid in altered adipogenesis, resulting in increased fat accumulation. This finding is the first report of a potential link between neonicotinoid insecticide exposure and lipid accumulation in adipocytes. Further in vivo as well as epidemiological studies will be required before we can extrapolate these findings to a potential contribution of imidacloprid in human obesity.

Original languageEnglish
Pages (from-to)255-259
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Volume61
Issue number1
DOIs
StatePublished - 9 Jan 2013

Fingerprint

Dive into the research topics of 'Imidacloprid, a neonicotinoid insecticide, potentiates adipogenesis in 3T3-L1 adipocytes'. Together they form a unique fingerprint.

Cite this