Impact of inhalation exposure to cigarette smoke on the pathogenesis of pulmonary hypertension primed by monocrotaline in rats

Jung Min Park, Yoon Seok Seo, Sung Hwan Kim, Hyeon Young Kim, Min Seok Kim, Moo Yeol Lee

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Extensive, long-term exposure to cigarette smoke (CS) was recently suggested to be a risk factor for pulmonary hypertension, although further validation is required. The vascular effects of CS share similarities with the etiology of pulmonary hypertension, including vascular inflammation and remodeling. Thus, we examined the influence of CS exposure on the pathogenesis of monocrotaline (MCT)-induced pulmonary hypertension, hypothesizing that smoking might accelerate the development of primed pulmonary hypertension. CS was generated from 3R4F reference cigarettes, and rats were exposed to CS by inhalation at total particulate matter concentrations of 100–300 μg/L for 4 h/day, 7 days/week for 4 weeks. Following 1 week of initial exposure, rats received 60 mg/kg MCT and were sacrificed and analyzed after an additional 3 weeks of exposure. MCT induced hypertrophy in pulmonary arterioles and increased the Fulton index, a measure of right ventricular hypertrophy. Additional CS exposure exacerbated arteriolar hypertrophy but did not further elevate the Fulton index. No significant alterations were observed in levels of endothelin-1 and vascular endothelial growth factor, or in hematological and serum biochemical parameters. Short-term inhalation exposure to CS exacerbated arteriolar hypertrophy in the lung, although this effect did not directly aggravate the overworked heart under the current experimental conditions.

Original languageEnglish
Pages (from-to)470-483
Number of pages14
JournalJournal of Applied Toxicology
Volume44
Issue number3
DOIs
StatePublished - Mar 2024

Keywords

  • arteriolar hypertrophy
  • cigarette smoke
  • monocrotaline
  • pulmonary hypertension
  • smoking

Fingerprint

Dive into the research topics of 'Impact of inhalation exposure to cigarette smoke on the pathogenesis of pulmonary hypertension primed by monocrotaline in rats'. Together they form a unique fingerprint.

Cite this