In vitro controlled release of tuberculosis drugs by amphiphilic branched copolymer nanoparticles

Mani Gajendiran; Heejung Jo; Kyobum Kim; Sengottuvelan Balasubramanian

doi:10.1016/j.jiec.2019.04.033

In vitro controlled release of tuberculosis drugs by amphiphilic branched copolymer nanoparticles

Mani Gajendiran, Heejung Jo, Kyobum Kim, Sengottuvelan Balasubramanian

Department of Chemical and Biochemical Engineering

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Poly(lactic-co-glycolic acid) (PLGA)-poly ethylene glycol (PEG) based amphiphilic branched copolymer nanoparticles (NPs) have been developed for controlled release of tuberculosis (TB) drugs which include rifampicin (RIF), isoniazid (INH) and pyrazinamide (PYZ). The drug loading efficiency and the percentage drug content of polymer NPs increase by increasing the amount of PEG content in polymer NPs. The branched PLGA-PEG based copolymer NPs exhibit initial burst release followed by sustained release of RIF for 840 h, INH for 72 h, and PYZ for 720 h. The branched citrate-PEG-PLGA copolymer NPs can act as potential drug carriers when compared to their linear analogues.

Original language	English
Pages (from-to)	181-188
Number of pages	8
Journal	Journal of Industrial and Engineering Chemistry
Volume	77
DOIs	https://doi.org/10.1016/j.jiec.2019.04.033
State	Published - 25 Sep 2019

Keywords

Citrate-PEG-PLGA branched copolymer
In vitro drug release
Isoniazid
Polymer nanoparticles
Pyrazinamide
Rifampicin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiec.2019.04.033

Cite this

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title = "In vitro controlled release of tuberculosis drugs by amphiphilic branched copolymer nanoparticles",

abstract = "Poly(lactic-co-glycolic acid) (PLGA)-poly ethylene glycol (PEG) based amphiphilic branched copolymer nanoparticles (NPs) have been developed for controlled release of tuberculosis (TB) drugs which include rifampicin (RIF), isoniazid (INH) and pyrazinamide (PYZ). The drug loading efficiency and the percentage drug content of polymer NPs increase by increasing the amount of PEG content in polymer NPs. The branched PLGA-PEG based copolymer NPs exhibit initial burst release followed by sustained release of RIF for 840 h, INH for 72 h, and PYZ for 720 h. The branched citrate-PEG-PLGA copolymer NPs can act as potential drug carriers when compared to their linear analogues.",

keywords = "Citrate-PEG-PLGA branched copolymer, In vitro drug release, Isoniazid, Polymer nanoparticles, Pyrazinamide, Rifampicin",

author = "Mani Gajendiran and Heejung Jo and Kyobum Kim and Sengottuvelan Balasubramanian",

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doi = "10.1016/j.jiec.2019.04.033",

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T1 - In vitro controlled release of tuberculosis drugs by amphiphilic branched copolymer nanoparticles

AU - Gajendiran, Mani

AU - Jo, Heejung

AU - Kim, Kyobum

AU - Balasubramanian, Sengottuvelan

PY - 2019/9/25

Y1 - 2019/9/25

N2 - Poly(lactic-co-glycolic acid) (PLGA)-poly ethylene glycol (PEG) based amphiphilic branched copolymer nanoparticles (NPs) have been developed for controlled release of tuberculosis (TB) drugs which include rifampicin (RIF), isoniazid (INH) and pyrazinamide (PYZ). The drug loading efficiency and the percentage drug content of polymer NPs increase by increasing the amount of PEG content in polymer NPs. The branched PLGA-PEG based copolymer NPs exhibit initial burst release followed by sustained release of RIF for 840 h, INH for 72 h, and PYZ for 720 h. The branched citrate-PEG-PLGA copolymer NPs can act as potential drug carriers when compared to their linear analogues.

AB - Poly(lactic-co-glycolic acid) (PLGA)-poly ethylene glycol (PEG) based amphiphilic branched copolymer nanoparticles (NPs) have been developed for controlled release of tuberculosis (TB) drugs which include rifampicin (RIF), isoniazid (INH) and pyrazinamide (PYZ). The drug loading efficiency and the percentage drug content of polymer NPs increase by increasing the amount of PEG content in polymer NPs. The branched PLGA-PEG based copolymer NPs exhibit initial burst release followed by sustained release of RIF for 840 h, INH for 72 h, and PYZ for 720 h. The branched citrate-PEG-PLGA copolymer NPs can act as potential drug carriers when compared to their linear analogues.

KW - Citrate-PEG-PLGA branched copolymer

KW - In vitro drug release

KW - Isoniazid

KW - Polymer nanoparticles

KW - Pyrazinamide

KW - Rifampicin

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SP - 181

EP - 188

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

ER -

In vitro controlled release of tuberculosis drugs by amphiphilic branched copolymer nanoparticles

Abstract

Keywords

UN SDGs

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