TY - JOUR
T1 - Inducing LTD-Like effect in the human motor cortex with low frequency and very short duration paired associative stimulation
T2 - An exploratory study
AU - Srivanitchapoom, Prachaya
AU - Park, Jung E.
AU - Thirugnanasambandam, Nivethida
AU - Panyakaew, Pattamon
AU - Ramos, Vesper Fe Marie
AU - Pandey, Sanjay
AU - Wu, Tianxia
AU - Hallett, Mark
N1 - Publisher Copyright:
© 2016 Prachaya Srivanitchapoom et al.
PY - 2016
Y1 - 2016
N2 - Introduction. Paired associative stimulation (PAS) is an established technique to investigate synaptic plasticity in the human motor cortex (M1). Classically, to induce long-term depression- (LTD-) or long-term potentiation-like effects in the human M1, studies have used low frequency and long duration trains of PAS. In the present study, we explored an LTD-like effect using very short duration and low frequency of P A S 10 m s protocols in human M1. Methods. Six protocols of low frequency P A S 10 m s (ranging from 0.2 Hz to 1 Hz) were investigated with very short durations of 1 and 2 minutes stimulation. Six healthy volunteers were included in each protocol. We obtained motor-evoked potentials from right abductor pollicis brevis muscle before and after applying P A S 10 m s up to 30 minutes. After we found P A S 10 m s protocol which induced an LTD-like effect, we tested that protocol on additional 5 subjects. Results. One-way repeated-measures ANOVA showed that only the group of 1-minute stimulation of 0.25 Hz induced an LTD-like effect. When adding the additional subjects, the effect remained and lasted for 30 minutes. Conclusion. Low frequency and very short duration of P A S 10 m s potentially induced an LTD-like effect in human M1. With further verification, this method might be useful for research relating to synaptic plasticity by reducing the duration of study and minimizing subject discomfort.
AB - Introduction. Paired associative stimulation (PAS) is an established technique to investigate synaptic plasticity in the human motor cortex (M1). Classically, to induce long-term depression- (LTD-) or long-term potentiation-like effects in the human M1, studies have used low frequency and long duration trains of PAS. In the present study, we explored an LTD-like effect using very short duration and low frequency of P A S 10 m s protocols in human M1. Methods. Six protocols of low frequency P A S 10 m s (ranging from 0.2 Hz to 1 Hz) were investigated with very short durations of 1 and 2 minutes stimulation. Six healthy volunteers were included in each protocol. We obtained motor-evoked potentials from right abductor pollicis brevis muscle before and after applying P A S 10 m s up to 30 minutes. After we found P A S 10 m s protocol which induced an LTD-like effect, we tested that protocol on additional 5 subjects. Results. One-way repeated-measures ANOVA showed that only the group of 1-minute stimulation of 0.25 Hz induced an LTD-like effect. When adding the additional subjects, the effect remained and lasted for 30 minutes. Conclusion. Low frequency and very short duration of P A S 10 m s potentially induced an LTD-like effect in human M1. With further verification, this method might be useful for research relating to synaptic plasticity by reducing the duration of study and minimizing subject discomfort.
UR - http://www.scopus.com/inward/record.url?scp=84958580877&partnerID=8YFLogxK
U2 - 10.1155/2016/3920298
DO - 10.1155/2016/3920298
M3 - Article
C2 - 26904298
AN - SCOPUS:84958580877
SN - 2090-5904
VL - 2016
JO - Neural Plasticity
JF - Neural Plasticity
M1 - 3920298
ER -