Abstract
Background: It has been suggested that variations in the inhibin α gene (INHA) may affect the ovarian function of women. This study was performed to investigate whether the genetic polymorphisms of the INHA gene are associated with idiopathic premature ovarian failure (POF) in a Korean population. Methods The subjects consisted of 159 idiopathic POF patients and 233 post-menopausal controls. Genotyping for the 16C>T polymorphism was performed by an minor groove binder (MGB) primer/probe Taqman assay, and the 124A>G polymorphism was identified using PCR restriction fragment length polymorphism analysis. Haplotypes were deduced by using the Haploview version 4.1. Results There were no significant differences in the genotype distributions or allele frequencies of the INHA gene 16C>T and 124A>G polymorphisms between the POF and the control group. Haplotype analysis also showed no significant difference between groups. Conclusions The distribution of the INHA gene promoter polymorphisms in a Korean POF population was not significantly different from controls, implying that the INHA gene polymorphisms may not be associated with the risk of idiopathic POF.
Original language | English |
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Pages (from-to) | 1870-1873 |
Number of pages | 4 |
Journal | Human Reproduction |
Volume | 27 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2012 |
Keywords
- Inhibin α
- Premature ovarian failure
- Single-nucleotide polymorphisms