Inhibin α gene promoter polymorphisms in Korean women with idiopathic premature ovarian failure

Sang Ho Yoon, Young Min Choi, Min A. Hong, Jin Ju Kim, Hyoung June Im, Gyoung Hoon Lee, Byung Moon Kang, Shin Yong Moon

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: It has been suggested that variations in the inhibin α gene (INHA) may affect the ovarian function of women. This study was performed to investigate whether the genetic polymorphisms of the INHA gene are associated with idiopathic premature ovarian failure (POF) in a Korean population. Methods The subjects consisted of 159 idiopathic POF patients and 233 post-menopausal controls. Genotyping for the 16C>T polymorphism was performed by an minor groove binder (MGB) primer/probe Taqman assay, and the 124A>G polymorphism was identified using PCR restriction fragment length polymorphism analysis. Haplotypes were deduced by using the Haploview version 4.1. Results There were no significant differences in the genotype distributions or allele frequencies of the INHA gene 16C>T and 124A>G polymorphisms between the POF and the control group. Haplotype analysis also showed no significant difference between groups. Conclusions The distribution of the INHA gene promoter polymorphisms in a Korean POF population was not significantly different from controls, implying that the INHA gene polymorphisms may not be associated with the risk of idiopathic POF.

Original languageEnglish
Pages (from-to)1870-1873
Number of pages4
JournalHuman Reproduction
Volume27
Issue number6
DOIs
StatePublished - Jun 2012

Keywords

  • Inhibin α
  • Premature ovarian failure
  • Single-nucleotide polymorphisms

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