Inhibition of the lipogenesis in liver and adipose tissue of diet-induced obese C57BL/6 mice by feeding oleic acid-rich sesame oil

Jeong Hoon Pan; Mi Jeong Kim; Jun Ho Kim; Yun Jeong Cho; Han Seung Shin; Jung Suk Sung; Tae Sik Park; Ho Geun Yoon; Sungjin Park; Young Jun Kim

doi:10.1007/s10068-015-0142-8

Inhibition of the lipogenesis in liver and adipose tissue of diet-induced obese C57BL/6 mice by feeding oleic acid-rich sesame oil

Jeong Hoon Pan, Mi Jeong Kim, Jun Ho Kim, Yun Jeong Cho, Han Seung Shin, Jung Suk Sung, Tae Sik Park, Ho Geun Yoon, Sungjin Park, Young Jun Kim

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The effects of sesame oil (SO) on lipogenic gene expression and lipid metabolism were observed. One percent of SO was added into the high-fat diet (HFD) used to feed C57BL/6 male mice for 8 weeks. SO significantly lowered adipose tissue mass than that of the high-fat control group. In addition, serum and hepatic lipid contents were markedly lower than those of the high-fat control group. Especially, the ratio of HDL/LDL was much higher than that of the HFD group. The gene expression of key lipogenic enzymes, Ppar-γ, Srebp-1c, Scd-1, Fas, Acc, Lpl, and malic enzyme, was significantly downregulated in the liver and adipose tissue of mice fed sesame oil. This study suggests that high proportion of oleic acid in SO might be strongly associated with lowering serum and hepatic lipid profile and suppressing lipogenic gene expression.

Original language	English
Pages (from-to)	1115-1121
Number of pages	7
Journal	Food Science and Biotechnology
Volume	24
Issue number	3
DOIs	https://doi.org/10.1007/s10068-015-0142-8
State	Published - 26 Jun 2015

Keywords

lipid profile
lipogenic gene
obesity
oleic acid
sesame oil

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10068-015-0142-8

Cite this

@article{4983031343634fbc90fb656b5566a06a,

title = "Inhibition of the lipogenesis in liver and adipose tissue of diet-induced obese C57BL/6 mice by feeding oleic acid-rich sesame oil",

abstract = "The effects of sesame oil (SO) on lipogenic gene expression and lipid metabolism were observed. One percent of SO was added into the high-fat diet (HFD) used to feed C57BL/6 male mice for 8 weeks. SO significantly lowered adipose tissue mass than that of the high-fat control group. In addition, serum and hepatic lipid contents were markedly lower than those of the high-fat control group. Especially, the ratio of HDL/LDL was much higher than that of the HFD group. The gene expression of key lipogenic enzymes, Ppar-γ, Srebp-1c, Scd-1, Fas, Acc, Lpl, and malic enzyme, was significantly downregulated in the liver and adipose tissue of mice fed sesame oil. This study suggests that high proportion of oleic acid in SO might be strongly associated with lowering serum and hepatic lipid profile and suppressing lipogenic gene expression.",

keywords = "lipid profile, lipogenic gene, obesity, oleic acid, sesame oil",

author = "Pan, {Jeong Hoon} and Kim, {Mi Jeong} and Kim, {Jun Ho} and Cho, {Yun Jeong} and Shin, {Han Seung} and Sung, {Jung Suk} and Park, {Tae Sik} and Yoon, {Ho Geun} and Sungjin Park and Kim, {Young Jun}",

note = "Publisher Copyright: {\textcopyright} 2015, The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht.",

year = "2015",

month = jun,

day = "26",

doi = "10.1007/s10068-015-0142-8",

language = "English",

volume = "24",

pages = "1115--1121",

journal = "Food Science and Biotechnology",

issn = "1226-7708",

publisher = "The Korean Society of Food Science and Technology",

number = "3",

}

TY - JOUR

T1 - Inhibition of the lipogenesis in liver and adipose tissue of diet-induced obese C57BL/6 mice by feeding oleic acid-rich sesame oil

AU - Pan, Jeong Hoon

AU - Kim, Mi Jeong

AU - Kim, Jun Ho

AU - Cho, Yun Jeong

AU - Shin, Han Seung

AU - Sung, Jung Suk

AU - Park, Tae Sik

AU - Yoon, Ho Geun

AU - Park, Sungjin

AU - Kim, Young Jun

PY - 2015/6/26

Y1 - 2015/6/26

N2 - The effects of sesame oil (SO) on lipogenic gene expression and lipid metabolism were observed. One percent of SO was added into the high-fat diet (HFD) used to feed C57BL/6 male mice for 8 weeks. SO significantly lowered adipose tissue mass than that of the high-fat control group. In addition, serum and hepatic lipid contents were markedly lower than those of the high-fat control group. Especially, the ratio of HDL/LDL was much higher than that of the HFD group. The gene expression of key lipogenic enzymes, Ppar-γ, Srebp-1c, Scd-1, Fas, Acc, Lpl, and malic enzyme, was significantly downregulated in the liver and adipose tissue of mice fed sesame oil. This study suggests that high proportion of oleic acid in SO might be strongly associated with lowering serum and hepatic lipid profile and suppressing lipogenic gene expression.

AB - The effects of sesame oil (SO) on lipogenic gene expression and lipid metabolism were observed. One percent of SO was added into the high-fat diet (HFD) used to feed C57BL/6 male mice for 8 weeks. SO significantly lowered adipose tissue mass than that of the high-fat control group. In addition, serum and hepatic lipid contents were markedly lower than those of the high-fat control group. Especially, the ratio of HDL/LDL was much higher than that of the HFD group. The gene expression of key lipogenic enzymes, Ppar-γ, Srebp-1c, Scd-1, Fas, Acc, Lpl, and malic enzyme, was significantly downregulated in the liver and adipose tissue of mice fed sesame oil. This study suggests that high proportion of oleic acid in SO might be strongly associated with lowering serum and hepatic lipid profile and suppressing lipogenic gene expression.

KW - lipid profile

KW - lipogenic gene

KW - obesity

KW - oleic acid

KW - sesame oil

UR - http://www.scopus.com/inward/record.url?scp=84930201405&partnerID=8YFLogxK

U2 - 10.1007/s10068-015-0142-8

DO - 10.1007/s10068-015-0142-8

M3 - Article

AN - SCOPUS:84930201405

SN - 1226-7708

VL - 24

SP - 1115

EP - 1121

JO - Food Science and Biotechnology

JF - Food Science and Biotechnology

IS - 3

ER -

Inhibition of the lipogenesis in liver and adipose tissue of diet-induced obese C57BL/6 mice by feeding oleic acid-rich sesame oil

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this