Inorganic nanomedicines and their labeling for biological imaging

Kyoung Min Kim, Joo Hee Kang, Ajayan Vinu, Jin Ho Choy, Jae Min Oh

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

In this review, we are going to demonstrate the recent progresses in inorganic nanomaterial-based nanomedicines and their labeling for effective biological imaging. Nanomaterials which are classified according to their dimensionality, from zero- to three-dimensions can be utilized as nanomedicines including drug delivery, therapy and diagnosis. In the following section, the labeling of nanomaterials with various contrasting agents are introduced. Various labeling agents like fluorescence, quantum dots, upconversion nanoparticles, magnetic particles and radioisotopes can be tagged on nanomaterials for effective imaging such as optical, magnetic resonance, computed tomography, positron emission tomography and etc. The labeling of contrasting agent on nanomedicine can be summarized into intercalation, surface modification, embedment and combination depending on how and where the label is tagged. Through these approaches, multimodal biological imaging and multifunctional nanomedicine could be suggested.

Original languageEnglish
Pages (from-to)488-503
Number of pages16
JournalCurrent Topics in Medicinal Chemistry
Volume13
Issue number4
DOIs
StatePublished - 2013

Keywords

  • Biological imaging
  • Contrasting agent
  • Diagnosis
  • Drug delivery
  • Inorganic nanomedicine
  • Labeling
  • Therapy

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