TY - GEN
T1 - Integrative meta-analysis of transcriptome data for unmasking biological mechanism of idiopathic pulmonary fibrosis
AU - Park, Sungmin
AU - Jung, Junghyun
AU - Joo, Jong Wha Joanne
N1 - Publisher Copyright:
© 2020 IEEE.
PY - 2020/12/5
Y1 - 2020/12/5
N2 - Idiopathic pulmonary fibrosis is one of the chronic and fatal interstitial lung diseases. IPF generally shows poor prognosis, and their exact pathogenesis and casualties are not clearly revealed yet. RNA sequencing and microarray experiments enable the determination of genes whose expression levels are significantly different in IPF disease group compared with the healthy control group. Total 749 genes were identified as differentially expressed genes in both two data sets via (P-value < 0.05) via oligo, limma, and DESeq R packages. Among total DEGs, 453 genes were significantly up-regulated genes and 250 genes were down-regulated genes. In order to confirm the systemic functions of the obtained DEGs, we performed gene set enrichment analysis and functional annotation by database for Annotation, Visualization, and Integrated Discovery.
AB - Idiopathic pulmonary fibrosis is one of the chronic and fatal interstitial lung diseases. IPF generally shows poor prognosis, and their exact pathogenesis and casualties are not clearly revealed yet. RNA sequencing and microarray experiments enable the determination of genes whose expression levels are significantly different in IPF disease group compared with the healthy control group. Total 749 genes were identified as differentially expressed genes in both two data sets via (P-value < 0.05) via oligo, limma, and DESeq R packages. Among total DEGs, 453 genes were significantly up-regulated genes and 250 genes were down-regulated genes. In order to confirm the systemic functions of the obtained DEGs, we performed gene set enrichment analysis and functional annotation by database for Annotation, Visualization, and Integrated Discovery.
KW - Bioinformatics
KW - Genetic Markers
KW - Idiopathic pulmonary fibrosis
KW - Meta-analysis
KW - RNA-Seq
UR - http://www.scopus.com/inward/record.url?scp=85100405265&partnerID=8YFLogxK
U2 - 10.1109/SCISISIS50064.2020.9322727
DO - 10.1109/SCISISIS50064.2020.9322727
M3 - Conference contribution
AN - SCOPUS:85100405265
T3 - 2020 Joint 11th International Conference on Soft Computing and Intelligent Systems and 21st International Symposium on Advanced Intelligent Systems, SCIS-ISIS 2020
BT - 2020 Joint 11th International Conference on Soft Computing and Intelligent Systems and 21st International Symposium on Advanced Intelligent Systems, SCIS-ISIS 2020
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - Joint 11th International Conference on Soft Computing and Intelligent Systems and 21st International Symposium on Advanced Intelligent Systems, SCIS-ISIS 2020
Y2 - 5 December 2020 through 8 December 2020
ER -