TY - JOUR
T1 - Integrative toxicogenomics-based approach to risk assessment of heavy metal mixtures/complexes
T2 - strategies and challenges
AU - Koedrith, Preeyaporn
AU - Kim, Hye Lim
AU - Seo, Young Rok
N1 - Publisher Copyright:
© 2015, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media Dordrecht.
PY - 2015/9/3
Y1 - 2015/9/3
N2 - Human exposure to metallic elements ranging from single metal ionic salt, metal compounds, and metal mixtures that may occur naturally, as well as from human activities and industrial applications. Some metals including arsenic, cadmium, chromium, lead, mercury, and nickel in both single element and mixture forms render confounding health effects and ultimately cause cancer. Studies of heavy metal-mediated global aberration using non-targeted multiple toxicogenomic technologies might help to elucidate environmentally relevant disorders, as well as to monitor biomarker of exposure and predict the health risk toward environmental toxicants. We describe recent toxicogenomic studies on heavy metal mixtures as well as relevant mechanism of toxicity and molecular signatures. On the basis of system toxicology approach, integrative toxicogenomic and bioinformatic tools might represent the biological pathways linked to disorders. We also strongly suggest that the toxicogenomic data can be adopted to risk assessment process. Furthermore, we mention challenges in utility of toxicogenomic studies data to risk assessment process of toxicity of metal mixtures. Overall, we realize that application and interpretation of toxicogenomic data regarding to their strengths and weaknesses would potentiate chemical risk assessment.
AB - Human exposure to metallic elements ranging from single metal ionic salt, metal compounds, and metal mixtures that may occur naturally, as well as from human activities and industrial applications. Some metals including arsenic, cadmium, chromium, lead, mercury, and nickel in both single element and mixture forms render confounding health effects and ultimately cause cancer. Studies of heavy metal-mediated global aberration using non-targeted multiple toxicogenomic technologies might help to elucidate environmentally relevant disorders, as well as to monitor biomarker of exposure and predict the health risk toward environmental toxicants. We describe recent toxicogenomic studies on heavy metal mixtures as well as relevant mechanism of toxicity and molecular signatures. On the basis of system toxicology approach, integrative toxicogenomic and bioinformatic tools might represent the biological pathways linked to disorders. We also strongly suggest that the toxicogenomic data can be adopted to risk assessment process. Furthermore, we mention challenges in utility of toxicogenomic studies data to risk assessment process of toxicity of metal mixtures. Overall, we realize that application and interpretation of toxicogenomic data regarding to their strengths and weaknesses would potentiate chemical risk assessment.
KW - Environment
KW - Heavy metal
KW - Risk assessment
KW - System toxicology
KW - Toxicogenomics
UR - http://www.scopus.com/inward/record.url?scp=84942894372&partnerID=8YFLogxK
U2 - 10.1007/s13273-015-0026-2
DO - 10.1007/s13273-015-0026-2
M3 - Review article
AN - SCOPUS:84942894372
SN - 1738-642X
VL - 11
SP - 265
EP - 276
JO - Molecular and Cellular Toxicology
JF - Molecular and Cellular Toxicology
IS - 3
ER -