Iodixanol-induced fixed drug eruption diagnosed by systemic provocation test

Sang Yun Jin; Do Hun Kim; Yun Seok Choi; Jae Hyun Kwon; Ai Young Lee; Seung Ho Lee

Iodixanol-induced fixed drug eruption diagnosed by systemic provocation test

Sang Yun Jin, Do Hun Kim, Yun Seok Choi, Jae Hyun Kwon, Ai Young Lee, Seung Ho Lee

Department of Medicine

Dongguk University

Research output: Contribution to journal › Article › peer-review

Abstract

Most cases of delayed skin reactions attributed to non-ionic iodinated contrast media, reported to date, have been maculopapular rash, which frequently occurs on me trunk and proximal region of me extremities. Only few cases of fixed drug eruption caused by non-ionic iodinated contrast media have been reported. A 48-year-old man developed multiple sharply marginated, hyperpigmented, oval patches on the trunk and extremities after receiving iodixanol (Visipaque^®, GE healthcare, USA). The patch test was carried out with a panel of the available iodinated non-ionic contrast media, but did not induce a positive reaction to any of the tested contrast media. The provocation test was carried out with iodixanol as 1/10 of the amount administered during me procedure that caused the reaction. On the following morning, the lesions increased in size and number. We report a case of iodixanol-induced fixed drug eruption, diagnosed by a systemic provocation test.

Original language	English
Pages (from-to)	1073-1076
Number of pages	4
Journal	Korean Journal of Dermatology
Volume	50
Issue number	12
State	Published - Dec 2012

Keywords

Contrast media
Delayed reactions
Fixed drug eruption
Iodixanol
Systemic provocation test

Cite this

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title = "Iodixanol-induced fixed drug eruption diagnosed by systemic provocation test",

abstract = "Most cases of delayed skin reactions attributed to non-ionic iodinated contrast media, reported to date, have been maculopapular rash, which frequently occurs on me trunk and proximal region of me extremities. Only few cases of fixed drug eruption caused by non-ionic iodinated contrast media have been reported. A 48-year-old man developed multiple sharply marginated, hyperpigmented, oval patches on the trunk and extremities after receiving iodixanol (Visipaque{\textregistered}, GE healthcare, USA). The patch test was carried out with a panel of the available iodinated non-ionic contrast media, but did not induce a positive reaction to any of the tested contrast media. The provocation test was carried out with iodixanol as 1/10 of the amount administered during me procedure that caused the reaction. On the following morning, the lesions increased in size and number. We report a case of iodixanol-induced fixed drug eruption, diagnosed by a systemic provocation test.",

keywords = "Contrast media, Delayed reactions, Fixed drug eruption, Iodixanol, Systemic provocation test",

author = "Jin, {Sang Yun} and Kim, {Do Hun} and Choi, {Yun Seok} and Kwon, {Jae Hyun} and Lee, {Ai Young} and Lee, {Seung Ho}",

year = "2012",

month = dec,

language = "English",

volume = "50",

pages = "1073--1076",

journal = "Korean Journal of Dermatology",

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publisher = "Korean Dermatological Association",

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TY - JOUR

T1 - Iodixanol-induced fixed drug eruption diagnosed by systemic provocation test

AU - Jin, Sang Yun

AU - Kim, Do Hun

AU - Choi, Yun Seok

AU - Kwon, Jae Hyun

AU - Lee, Ai Young

AU - Lee, Seung Ho

PY - 2012/12

Y1 - 2012/12

N2 - Most cases of delayed skin reactions attributed to non-ionic iodinated contrast media, reported to date, have been maculopapular rash, which frequently occurs on me trunk and proximal region of me extremities. Only few cases of fixed drug eruption caused by non-ionic iodinated contrast media have been reported. A 48-year-old man developed multiple sharply marginated, hyperpigmented, oval patches on the trunk and extremities after receiving iodixanol (Visipaque®, GE healthcare, USA). The patch test was carried out with a panel of the available iodinated non-ionic contrast media, but did not induce a positive reaction to any of the tested contrast media. The provocation test was carried out with iodixanol as 1/10 of the amount administered during me procedure that caused the reaction. On the following morning, the lesions increased in size and number. We report a case of iodixanol-induced fixed drug eruption, diagnosed by a systemic provocation test.

AB - Most cases of delayed skin reactions attributed to non-ionic iodinated contrast media, reported to date, have been maculopapular rash, which frequently occurs on me trunk and proximal region of me extremities. Only few cases of fixed drug eruption caused by non-ionic iodinated contrast media have been reported. A 48-year-old man developed multiple sharply marginated, hyperpigmented, oval patches on the trunk and extremities after receiving iodixanol (Visipaque®, GE healthcare, USA). The patch test was carried out with a panel of the available iodinated non-ionic contrast media, but did not induce a positive reaction to any of the tested contrast media. The provocation test was carried out with iodixanol as 1/10 of the amount administered during me procedure that caused the reaction. On the following morning, the lesions increased in size and number. We report a case of iodixanol-induced fixed drug eruption, diagnosed by a systemic provocation test.

KW - Contrast media

KW - Delayed reactions

KW - Fixed drug eruption

KW - Iodixanol

KW - Systemic provocation test

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M3 - Article

AN - SCOPUS:84872137118

SN - 0494-4739

VL - 50

SP - 1073

EP - 1076

JO - Korean Journal of Dermatology

JF - Korean Journal of Dermatology

IS - 12

ER -

Iodixanol-induced fixed drug eruption diagnosed by systemic provocation test

Abstract

Keywords

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