Isolation of a lignan-enriched fraction from Schisandra chinensis and its effective solubilization via poloxamer 407-based solid dispersion formulation

Young Hee Choi, Young Won Chin, Seung Jun Yang, Pisey Pel, You Jin Kim, Eun Young Kim, Hyo Kyung Han

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

This study aimed to isolate a lignan-enriched fraction from Schisandra chinensis and improve the dissolution of biologically active lignans via solid dispersion (SD) formulation. Lignan-enriched fraction was obtained from a hexane-soluble extraction, being poorly soluble in water. To improve the dissolution of major lignans from these extracts, SD formulation of an isolated extract was prepared with different hydrophilic polymers. Among the tested carriers, poloxamer 407 was most effective in enhancing the release of active lignans from extract. Compared to the pure extract, poloxamer 407-based SD significantly increased the dissolution of nine active lignans (schisandrol A, gomisin J, schisandrol B, tigloylgomisin H, angeloylgomisin H, schisandrin A, schisandrin B, gomisin N, schisandrin C) by 1.6- to 300-fold in water. SD also lead to the solidification of sticky extract, providing better flowability and ease of handling. Collectively, poloxamer 407-based SD formulation appeared to be effective in enhancing the dissolution of the active lignans from S. Chinensis.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalJournal of Pharmaceutical Investigation
Volume46
Issue number2
DOIs
StatePublished - 1 Apr 2016

Keywords

  • Dissolution
  • Formulation
  • Lignans
  • Schisandra chinensis
  • Solid dispersion
  • Solubilization

Fingerprint

Dive into the research topics of 'Isolation of a lignan-enriched fraction from Schisandra chinensis and its effective solubilization via poloxamer 407-based solid dispersion formulation'. Together they form a unique fingerprint.

Cite this