Itraconazole-Laponite: Kinetics and mechanism of drug release

Hyun Jung, Hyun Mi Kim, Young Bin Choy, Seong Ju Hwang, Jin Ho Choy

Research output: Contribution to journalArticlepeer-review

102 Scopus citations

Abstract

A clay-drug nanohybrid was prepared by interfacial boundary ion exchange reaction, from which the release mechanism of a poorly water soluble drug, itraconazole, was studied systematically. The effect of cation types on drug release was investigated on the basis of a UPS 25 guide line and the effect of Laponite dissolution was also studied at pH = 1.2. To describe the release patterns, mathematical modeling was preformed using first-order, Elovich, parabolic diffusion, and power function equations.

Original languageEnglish
Pages (from-to)99-107
Number of pages9
JournalApplied Clay Science
Volume40
Issue number1-4
DOIs
StatePublished - Jun 2008

Keywords

  • Controlled release
  • Intercalation reaction
  • Itraconazole
  • Nanohybrid
  • Smectite clay

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