Abstract
A clay-drug nanohybrid was prepared by interfacial boundary ion exchange reaction, from which the release mechanism of a poorly water soluble drug, itraconazole, was studied systematically. The effect of cation types on drug release was investigated on the basis of a UPS 25 guide line and the effect of Laponite dissolution was also studied at pH = 1.2. To describe the release patterns, mathematical modeling was preformed using first-order, Elovich, parabolic diffusion, and power function equations.
Original language | English |
---|---|
Pages (from-to) | 99-107 |
Number of pages | 9 |
Journal | Applied Clay Science |
Volume | 40 |
Issue number | 1-4 |
DOIs | |
State | Published - Jun 2008 |
Keywords
- Controlled release
- Intercalation reaction
- Itraconazole
- Nanohybrid
- Smectite clay