Itraconazole-Laponite: Kinetics and mechanism of drug release

Hyun Jung; Hyun Mi Kim; Young Bin Choy; Seong Ju Hwang; Jin Ho Choy

doi:10.1016/j.clay.2007.09.002

Itraconazole-Laponite: Kinetics and mechanism of drug release

Hyun Jung
, Hyun Mi Kim
, Young Bin Choy
, Seong Ju Hwang
, Jin Ho Choy

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

A clay-drug nanohybrid was prepared by interfacial boundary ion exchange reaction, from which the release mechanism of a poorly water soluble drug, itraconazole, was studied systematically. The effect of cation types on drug release was investigated on the basis of a UPS 25 guide line and the effect of Laponite dissolution was also studied at pH = 1.2. To describe the release patterns, mathematical modeling was preformed using first-order, Elovich, parabolic diffusion, and power function equations.

Original language	English
Pages (from-to)	99-107
Number of pages	9
Journal	Applied Clay Science
Volume	40
Issue number	1-4
DOIs	https://doi.org/10.1016/j.clay.2007.09.002
State	Published - Jun 2008

Keywords

Controlled release
Intercalation reaction
Itraconazole
Nanohybrid
Smectite clay

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10.1016/j.clay.2007.09.002

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title = "Itraconazole-Laponite: Kinetics and mechanism of drug release",

abstract = "A clay-drug nanohybrid was prepared by interfacial boundary ion exchange reaction, from which the release mechanism of a poorly water soluble drug, itraconazole, was studied systematically. The effect of cation types on drug release was investigated on the basis of a UPS 25 guide line and the effect of Laponite dissolution was also studied at pH = 1.2. To describe the release patterns, mathematical modeling was preformed using first-order, Elovich, parabolic diffusion, and power function equations.",

keywords = "Controlled release, Intercalation reaction, Itraconazole, Nanohybrid, Smectite clay",

author = "Hyun Jung and Kim, \{Hyun Mi\} and Choy, \{Young Bin\} and Hwang, \{Seong Ju\} and Choy, \{Jin Ho\}",

year = "2008",

month = jun,

doi = "10.1016/j.clay.2007.09.002",

language = "English",

volume = "40",

pages = "99--107",

journal = "Applied Clay Science",

issn = "0169-1317",

publisher = "Elsevier B.V.",

number = "1-4",

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TY - JOUR

T1 - Itraconazole-Laponite

T2 - Kinetics and mechanism of drug release

AU - Jung, Hyun

AU - Kim, Hyun Mi

AU - Choy, Young Bin

AU - Hwang, Seong Ju

AU - Choy, Jin Ho

PY - 2008/6

Y1 - 2008/6

N2 - A clay-drug nanohybrid was prepared by interfacial boundary ion exchange reaction, from which the release mechanism of a poorly water soluble drug, itraconazole, was studied systematically. The effect of cation types on drug release was investigated on the basis of a UPS 25 guide line and the effect of Laponite dissolution was also studied at pH = 1.2. To describe the release patterns, mathematical modeling was preformed using first-order, Elovich, parabolic diffusion, and power function equations.

AB - A clay-drug nanohybrid was prepared by interfacial boundary ion exchange reaction, from which the release mechanism of a poorly water soluble drug, itraconazole, was studied systematically. The effect of cation types on drug release was investigated on the basis of a UPS 25 guide line and the effect of Laponite dissolution was also studied at pH = 1.2. To describe the release patterns, mathematical modeling was preformed using first-order, Elovich, parabolic diffusion, and power function equations.

KW - Controlled release

KW - Intercalation reaction

KW - Itraconazole

KW - Nanohybrid

KW - Smectite clay

UR - https://www.scopus.com/pages/publications/44349148498

U2 - 10.1016/j.clay.2007.09.002

DO - 10.1016/j.clay.2007.09.002

M3 - Article

AN - SCOPUS:44349148498

SN - 0169-1317

VL - 40

SP - 99

EP - 107

JO - Applied Clay Science

JF - Applied Clay Science

IS - 1-4

ER -

Itraconazole-Laponite: Kinetics and mechanism of drug release

Abstract

Keywords

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