Abstract
The pathogenic link between POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes, and various other clinical signs) syndrome and Castleman's disease is unclear. Roles for M protein in POEMS syndrome and cytokines in systemic manifestations of multicentric Castleman's disease have been suggested. Recently, pathogenic roles of cytokines in POEMS syndrome and Kaposi's sarcoma-associated herpesvirus (KSHV) in Castleman's disease have been reported. We report on a patient with KSHV-associated Castleman's disease with POEMS syndrome, and suggest a possible role of KSHV in initiating and linking these two diseases. (C) 2000 John Wiley and Sons, Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 436-439 |
| Number of pages | 4 |
| Journal | Muscle and Nerve |
| Volume | 23 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2000 |
Keywords
- Castleman's disease
- Cytokine
- Kaposi's sarcoma-associated herpes-virus
- M protein
- POEMS syndrome