TY - JOUR
T1 - Key Health Benefits of Korean Ueong Dry Root Extract Combined Silver Nanoparticles
AU - Das, Gitishree
AU - Shin, Han Seung
AU - Patra, Jayanta Kumar
N1 - Publisher Copyright:
© 2022 Das et al.
PY - 2022
Y1 - 2022
N2 - Introduction: Nowadays, in nanotechnology and material science, biosynthesis of the metal nanoparticle is a promising approach. Methods: In the current research, the extract of the Korean Ueong dry root (BdkR), which belongs to the Asteraceae family, was used as a reducing and capping agent, for the green synthesis of the BdkR-Ag nanoparticles in a cost-effective and highly efficient manner. In this study for the reaction measures, UV-Vis spectroscopy was applied. SEM, EDX, FTIR, XRD, mean size distribution, and zeta potential were used for the characterization of the green synthesized BdkR-AgNPs. In the beginning, the primary phytochemical screening of BdkR extract was estimated and the cytotoxicity, antidiabetic, antioxidant, and antibacterial activities of the green synthesized BdkR-AgNPs were evaluated. Results: According to the results, the BdkR extract is rich in various phytochemicals and the generated AgNPs were crystalline in nature. The surface plasmon resonance value of the BdkR-AgNPs was 444 nm confirming the synthesis of AgNPs. The BdkR-AgNPs displayed four clear diffraction peaks at 2 theta angles (38.22); (46.15); (64.88); (76.83), respectively, which are equivalent to (111), (200), (220) and (311). The obtained nanoparticles have a zeta potential of −17.0 mV. Furthermore, the generated BdkR-AgNPs exhibited consider-able antidiabetic effect in terms of the inhibition of α-glucosidase with a maximum inhibition value of 95.41% at 5.0 µg/mL and more than 86% inhibition at 2.5 µg/mL and the estimated IC50 value was found to be 0.653 µg/mL. Further, it also displayed a significant cytotoxicity activity against the HepG2 cancer cell lines at 10 µg/mL and 100 µg/mL concentrations with 86% and 88% of inhibition, respectively. Besides this, the synthesized AgNPs also displayed promising antioxidant activities in terms of the DPPH (IC50 value-56.26 µg/mL), ABTS (IC50 value-171.43 µg/mL) and reducing power (IC0.5 value-227.42 µg/mL). Discussion: The multipotential effects of the synthesized BdkR-AgNPs might be attributed to the presence of the bioactive compounds in the BdkR extract that acted as the capping and reducing agent in the synthesis process. The green synthesized BdkR-AgNPs exhibited promising bioactive potential for their future applications in the food and biomedical field.
AB - Introduction: Nowadays, in nanotechnology and material science, biosynthesis of the metal nanoparticle is a promising approach. Methods: In the current research, the extract of the Korean Ueong dry root (BdkR), which belongs to the Asteraceae family, was used as a reducing and capping agent, for the green synthesis of the BdkR-Ag nanoparticles in a cost-effective and highly efficient manner. In this study for the reaction measures, UV-Vis spectroscopy was applied. SEM, EDX, FTIR, XRD, mean size distribution, and zeta potential were used for the characterization of the green synthesized BdkR-AgNPs. In the beginning, the primary phytochemical screening of BdkR extract was estimated and the cytotoxicity, antidiabetic, antioxidant, and antibacterial activities of the green synthesized BdkR-AgNPs were evaluated. Results: According to the results, the BdkR extract is rich in various phytochemicals and the generated AgNPs were crystalline in nature. The surface plasmon resonance value of the BdkR-AgNPs was 444 nm confirming the synthesis of AgNPs. The BdkR-AgNPs displayed four clear diffraction peaks at 2 theta angles (38.22); (46.15); (64.88); (76.83), respectively, which are equivalent to (111), (200), (220) and (311). The obtained nanoparticles have a zeta potential of −17.0 mV. Furthermore, the generated BdkR-AgNPs exhibited consider-able antidiabetic effect in terms of the inhibition of α-glucosidase with a maximum inhibition value of 95.41% at 5.0 µg/mL and more than 86% inhibition at 2.5 µg/mL and the estimated IC50 value was found to be 0.653 µg/mL. Further, it also displayed a significant cytotoxicity activity against the HepG2 cancer cell lines at 10 µg/mL and 100 µg/mL concentrations with 86% and 88% of inhibition, respectively. Besides this, the synthesized AgNPs also displayed promising antioxidant activities in terms of the DPPH (IC50 value-56.26 µg/mL), ABTS (IC50 value-171.43 µg/mL) and reducing power (IC0.5 value-227.42 µg/mL). Discussion: The multipotential effects of the synthesized BdkR-AgNPs might be attributed to the presence of the bioactive compounds in the BdkR extract that acted as the capping and reducing agent in the synthesis process. The green synthesized BdkR-AgNPs exhibited promising bioactive potential for their future applications in the food and biomedical field.
KW - antidiabetic
KW - antioxidant
KW - cytotoxicity
KW - green synthesis
KW - silver nanoparticle
UR - http://www.scopus.com/inward/record.url?scp=85138000469&partnerID=8YFLogxK
U2 - 10.2147/IJN.S357343
DO - 10.2147/IJN.S357343
M3 - Article
C2 - 36134204
AN - SCOPUS:85138000469
SN - 1176-9114
VL - 17
SP - 4261
EP - 4275
JO - International Journal of Nanomedicine
JF - International Journal of Nanomedicine
ER -