Layered double hydroxide as an efficient drug reservoir for folate derivatives

Jin Ho Choy, Ji Sun Jung, Jae Min Oh, Man Park, Jinyoung Jeong, Young Koo Kang, Ok Jin Han

Research output: Contribution to journalArticlepeer-review

444 Scopus citations

Abstract

Folic acid derivatives such as folinic acid and methotrexate (MTX) have been successfully hybridized with layered double hydroxide (LDH) by ion-exchange reaction. The X-ray diffraction patterns and spectroscopic analyses indicate that these molecules intercalated into the hydroxide interlayer space are stabilized in the tilted longitudinal monolayer mode by electrostatic interaction. No significant changes in their structural and functional properties are found in the hybrids. The cellular uptake test of MTX-LDH hybrid is carried out in the fibroblast (human tendon) and SaOS-2 cell line (Osteosarcoma, human) by in vitro MTT (3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyl tetrazolium bromide) assay. The initial proliferation of SaOS-2 cell is more strongly suppressed by treatment with MTX-LDH hybrid than with MTX alone. This study clearly shows that LDH not only plays a role as a biocompatible-delivery matrix for drugs but also facilitates a significant increase in the delivery efficiency.

Original languageEnglish
Pages (from-to)3059-3064
Number of pages6
JournalBiomaterials
Volume25
Issue number15
DOIs
StatePublished - Jul 2004

Keywords

  • Drug delivery
  • Folate derivatives
  • Hybrid
  • Layered double hydroxide
  • Osteosarcoma (SaOS-2)

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