TY - JOUR
T1 - LDH nanocontainers as bio-reservoirs and drug delivery carriers
AU - Oh, Jae Min
AU - Park, Dae Hwan
AU - Choi, Soo Jin
AU - Choy, Jin Ho
PY - 2012
Y1 - 2012
N2 - This review outlines research and patents relating to the use of inorganic nanomaterial, layered double hydroxide, as nanocontainers for drug delivery and gene reservoirs. Various intercalative synthetic routes including coprecipitation, ion exchange, reconstruction and exfoliation-reassembly have been explored to incorporate drug or gene molecules. Its unique two-dimensional structure allows layered double hydroxide to act as a nanospace for the stabilization, targeted delivery or controlled release of gene or drug molecules. Intercalative hybrid nanomaterials have uses such as pharmaceutically active ingredients, in oral- or cellular delivery systems, cosmetic ingredients, molecular coding units and etc. Toxicological studies have found layered double hydroxides to be biocompatible compared with widely used nanoparticles such as iron oxide, silica, and single-walled carbon nanotubes. Due to their versatile functionality and biocompatibility, layered double hydroxides have been widely studied and their applicability can be expanded to other nanoparticle based bio-medical applications.
AB - This review outlines research and patents relating to the use of inorganic nanomaterial, layered double hydroxide, as nanocontainers for drug delivery and gene reservoirs. Various intercalative synthetic routes including coprecipitation, ion exchange, reconstruction and exfoliation-reassembly have been explored to incorporate drug or gene molecules. Its unique two-dimensional structure allows layered double hydroxide to act as a nanospace for the stabilization, targeted delivery or controlled release of gene or drug molecules. Intercalative hybrid nanomaterials have uses such as pharmaceutically active ingredients, in oral- or cellular delivery systems, cosmetic ingredients, molecular coding units and etc. Toxicological studies have found layered double hydroxides to be biocompatible compared with widely used nanoparticles such as iron oxide, silica, and single-walled carbon nanotubes. Due to their versatile functionality and biocompatibility, layered double hydroxides have been widely studied and their applicability can be expanded to other nanoparticle based bio-medical applications.
KW - Drug delivery system
KW - Gene reservoir
KW - Layered double hydroxides
KW - Molecular code system
KW - Nanomedicine
KW - Nanotoxicology
UR - http://www.scopus.com/inward/record.url?scp=84870186181&partnerID=8YFLogxK
U2 - 10.2174/187221012803531538
DO - 10.2174/187221012803531538
M3 - Review article
C2 - 22747720
AN - SCOPUS:84870186181
SN - 1872-2105
VL - 6
SP - 200
EP - 217
JO - Recent Patents on Nanotechnology
JF - Recent Patents on Nanotechnology
IS - 3
ER -