Abstract
Bioactivity-guided isolation of Opuntia ficus-indica (Cactaceae) seeds against ethanol-treated primary rat hepatocytes yielded six lignan compounds. Among the isolates, furofuran lignans 4-6, significantly protected rat hepatocytes against ethanol-induced oxidative stress by reducing intracellular reactive oxygen species levels, preserving antioxidative defense enzyme activities, and maintaining the glutathione content. Moreover, 4 dose-dependently induced the heme oxygenase-1 expression in HepG2 cells.
Original language | English |
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Pages (from-to) | 181-183 |
Number of pages | 3 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 81 |
Issue number | 1 |
DOIs | |
State | Published - 2017 |
Keywords
- Heme oxygenase-1
- Hepatoprotective activity
- Lignin
- Opuntia ficus-indica