Lignans from Opuntia ficus-indica seeds protect rat primary hepatocytes and HepG2 cells against ethanol-induced oxidative stress

Jung Wha Kim, Heejung Yang, Hyeon Woo Kim, Hong Pyo Kim, Sang Hyun Sung

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Bioactivity-guided isolation of Opuntia ficus-indica (Cactaceae) seeds against ethanol-treated primary rat hepatocytes yielded six lignan compounds. Among the isolates, furofuran lignans 4-6, significantly protected rat hepatocytes against ethanol-induced oxidative stress by reducing intracellular reactive oxygen species levels, preserving antioxidative defense enzyme activities, and maintaining the glutathione content. Moreover, 4 dose-dependently induced the heme oxygenase-1 expression in HepG2 cells.

Original languageEnglish
Pages (from-to)181-183
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume81
Issue number1
DOIs
StatePublished - 2017

Keywords

  • Heme oxygenase-1
  • Hepatoprotective activity
  • Lignin
  • Opuntia ficus-indica

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