Lipid-based surface engineering of PLGA nanoparticles for drug and gene delivery applications

Rajendran J.C. Bose; Soo Hong Lee; Hansoo Park

doi:10.1186/s40824-016-0081-3

Lipid-based surface engineering of PLGA nanoparticles for drug and gene delivery applications

Rajendran J.C. Bose
, Soo Hong Lee
, Hansoo Park

Department of Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

102 Scopus citations

Abstract

The use of poly(lactic-co-glycolic acid) (PLGA)-based nanocarriers presents several major challenges, including their synthetic hydrophobic surface, low transfection efficiency, short circulation half-life, and nonspecific tissue distribution. Numerous engineering strategies have been employed to overcome these problems, with lipid-based surface functionalization of PLGA nanoparticles (NPs) showing promising results in the development of PLGA-based clinical nanomedicines. Surface engineering with different lipids enhances the target specificity of the carrier and improves its physicochemical properties as well as NP-cell associations, such as cellular membrane permeability, immune responses, and long circulation half-life in vivo. This review focuses on recent advances in the lipid-based surface engineering of PLGA NPs for drug and gene delivery applications.

Original language	English
Article number	34
Journal	Biomaterials Research
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s40824-016-0081-3
State	Published - 2016

Keywords

Biomimetic fucntionalization
Cell membrane derived lipid vesicles
Controlled drug release
Gene delivery
Lipids
PLGA nanoparticle
Self assembly
Surface engineering

Access to Document

10.1186/s40824-016-0081-3

Cite this

@article{6e7a3b14fd544cf997d0e60e6e91e471,

title = "Lipid-based surface engineering of PLGA nanoparticles for drug and gene delivery applications",

abstract = "The use of poly(lactic-co-glycolic acid) (PLGA)-based nanocarriers presents several major challenges, including their synthetic hydrophobic surface, low transfection efficiency, short circulation half-life, and nonspecific tissue distribution. Numerous engineering strategies have been employed to overcome these problems, with lipid-based surface functionalization of PLGA nanoparticles (NPs) showing promising results in the development of PLGA-based clinical nanomedicines. Surface engineering with different lipids enhances the target specificity of the carrier and improves its physicochemical properties as well as NP-cell associations, such as cellular membrane permeability, immune responses, and long circulation half-life in vivo. This review focuses on recent advances in the lipid-based surface engineering of PLGA NPs for drug and gene delivery applications.",

keywords = "Biomimetic fucntionalization, Cell membrane derived lipid vesicles, Controlled drug release, Gene delivery, Lipids, PLGA nanoparticle, Self assembly, Surface engineering",

author = "Bose, \{Rajendran J.C.\} and Lee, \{Soo Hong\} and Hansoo Park",

note = "Publisher Copyright: {\textcopyright} 2016 The Author(s).",

year = "2016",

doi = "10.1186/s40824-016-0081-3",

language = "English",

volume = "20",

journal = "Biomaterials Research",

issn = "2055-7124",

publisher = "American Association for the Advancement of Science",

number = "1",

}

TY - JOUR

T1 - Lipid-based surface engineering of PLGA nanoparticles for drug and gene delivery applications

AU - Bose, Rajendran J.C.

AU - Lee, Soo Hong

AU - Park, Hansoo

PY - 2016

Y1 - 2016

N2 - The use of poly(lactic-co-glycolic acid) (PLGA)-based nanocarriers presents several major challenges, including their synthetic hydrophobic surface, low transfection efficiency, short circulation half-life, and nonspecific tissue distribution. Numerous engineering strategies have been employed to overcome these problems, with lipid-based surface functionalization of PLGA nanoparticles (NPs) showing promising results in the development of PLGA-based clinical nanomedicines. Surface engineering with different lipids enhances the target specificity of the carrier and improves its physicochemical properties as well as NP-cell associations, such as cellular membrane permeability, immune responses, and long circulation half-life in vivo. This review focuses on recent advances in the lipid-based surface engineering of PLGA NPs for drug and gene delivery applications.

AB - The use of poly(lactic-co-glycolic acid) (PLGA)-based nanocarriers presents several major challenges, including their synthetic hydrophobic surface, low transfection efficiency, short circulation half-life, and nonspecific tissue distribution. Numerous engineering strategies have been employed to overcome these problems, with lipid-based surface functionalization of PLGA nanoparticles (NPs) showing promising results in the development of PLGA-based clinical nanomedicines. Surface engineering with different lipids enhances the target specificity of the carrier and improves its physicochemical properties as well as NP-cell associations, such as cellular membrane permeability, immune responses, and long circulation half-life in vivo. This review focuses on recent advances in the lipid-based surface engineering of PLGA NPs for drug and gene delivery applications.

KW - Biomimetic fucntionalization

KW - Cell membrane derived lipid vesicles

KW - Controlled drug release

KW - Gene delivery

KW - Lipids

KW - PLGA nanoparticle

KW - Self assembly

KW - Surface engineering

UR - https://www.scopus.com/pages/publications/85020049342

U2 - 10.1186/s40824-016-0081-3

DO - 10.1186/s40824-016-0081-3

M3 - Review article

AN - SCOPUS:85020049342

SN - 2055-7124

VL - 20

JO - Biomaterials Research

JF - Biomaterials Research

IS - 1

M1 - 34

ER -

Lipid-based surface engineering of PLGA nanoparticles for drug and gene delivery applications

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this