TY - JOUR
T1 - Lipid polymer hybrid nanospheres encapsulating antiproliferative agents for stent applications
AU - Bose, Rajendran J.C.
AU - Lee, Soo Hong
AU - Park, Hansoo
N1 - Publisher Copyright:
© 2016 The Korean Society of Industrial and Engineering Chemistry.
PY - 2016/4/25
Y1 - 2016/4/25
N2 - Antiproliferative drug (sirolimus or propolis) loaded lipid polymer hybrid nanospheres (LPHNSs) were prepared by single step method. The effects of different lipids on properties of nanocarrier were investigated. Furthermore, anti proliferative efficiency and cytotoxicity of LPHHNSs-propolis or sirolimus were investigated on human aortic smooth muscle cells (HASMCs), and human aortic endothelial primary cells (HAECs) respectively. The characterization of LPHNSs revealed that the lipids used in the formulation influence physiochemical parameters. In vitro studies showed that the encapsulated sirolimus and propolis significantly reduced the proliferation of HASMCs, while maintaining high HAECs viability.
AB - Antiproliferative drug (sirolimus or propolis) loaded lipid polymer hybrid nanospheres (LPHNSs) were prepared by single step method. The effects of different lipids on properties of nanocarrier were investigated. Furthermore, anti proliferative efficiency and cytotoxicity of LPHHNSs-propolis or sirolimus were investigated on human aortic smooth muscle cells (HASMCs), and human aortic endothelial primary cells (HAECs) respectively. The characterization of LPHNSs revealed that the lipids used in the formulation influence physiochemical parameters. In vitro studies showed that the encapsulated sirolimus and propolis significantly reduced the proliferation of HASMCs, while maintaining high HAECs viability.
KW - Anti proliferation assessment
KW - Antiproliferative drugs
KW - Cytotoxicity on human aortic endothelial cells
KW - Human aortic smooth muscle cells
KW - Lipid polymer hybrid nanospheres
UR - http://www.scopus.com/inward/record.url?scp=84977834635&partnerID=8YFLogxK
U2 - 10.1016/j.jiec.2016.02.015
DO - 10.1016/j.jiec.2016.02.015
M3 - Article
AN - SCOPUS:84977834635
SN - 1226-086X
VL - 36
SP - 284
EP - 292
JO - Journal of Industrial and Engineering Chemistry
JF - Journal of Industrial and Engineering Chemistry
ER -