TY - JOUR
T1 - Liver carcinogenesis and formation of 8-hydroxy-deoxyguanosine in C3H/HeN mice by oxidized dietary oils containing carcinogenic dicarbonyl compounds
AU - Ichinose, T.
AU - Nobuyuki, S.
AU - Takano, H.
AU - Abe, M.
AU - Sadakane, K.
AU - Yanagisawa, R.
AU - Ochi, H.
AU - Fujioka, K.
AU - Lee, K. G.
AU - Shibamoto, T.
PY - 2004/11
Y1 - 2004/11
N2 - Oxidized dietary oils (lard, soybean oil, and sardine oil) were orally administered to C3H/HeN male mice. After 6 months, benign hepatocellular adenoma was observed in the mice treated with all three oxidized dietary oils. After 12 months, malignant hepatocellular carcinoma and hepatoblastoma were observed in addition to the benign tumor. Oxidized sardine oil caused the highest tumor incidence (35%) and malignant tumors (27.5%) among the oxidized dietary oils tested. Mice treated with oxidized lard and sardine oil exhibited a significant increase of 8-OH-dG in the livers. The amounts of 8-OH-dG found in the mice treated with oxidized sardine oil correlated with the rates of tumor incidence. After 6 months, mRNA decreased in the case of oxidized lard and sardine oil, whereas it increased in the case of oxidized soybean oil, either in 8-oxoguanine-DNA glycosylase (OGG1) or in 8-oxo-dGTPase. On the other hand, there was no appreciable change in mRNA, in either OGG1 or 8-oxo-dGTPase, after 12 months. Oxidized sardine oil contained the highest level of malonaldehyde (MA) (713 ± 91.1 nmol/g) and glyoxal (33.3 ± 5.2 nmol/g) among three oxidized oils. The malignant tumor incidence correlated with the high level of MA and glyoxal found in the dietary oils tested.
AB - Oxidized dietary oils (lard, soybean oil, and sardine oil) were orally administered to C3H/HeN male mice. After 6 months, benign hepatocellular adenoma was observed in the mice treated with all three oxidized dietary oils. After 12 months, malignant hepatocellular carcinoma and hepatoblastoma were observed in addition to the benign tumor. Oxidized sardine oil caused the highest tumor incidence (35%) and malignant tumors (27.5%) among the oxidized dietary oils tested. Mice treated with oxidized lard and sardine oil exhibited a significant increase of 8-OH-dG in the livers. The amounts of 8-OH-dG found in the mice treated with oxidized sardine oil correlated with the rates of tumor incidence. After 6 months, mRNA decreased in the case of oxidized lard and sardine oil, whereas it increased in the case of oxidized soybean oil, either in 8-oxoguanine-DNA glycosylase (OGG1) or in 8-oxo-dGTPase. On the other hand, there was no appreciable change in mRNA, in either OGG1 or 8-oxo-dGTPase, after 12 months. Oxidized sardine oil contained the highest level of malonaldehyde (MA) (713 ± 91.1 nmol/g) and glyoxal (33.3 ± 5.2 nmol/g) among three oxidized oils. The malignant tumor incidence correlated with the high level of MA and glyoxal found in the dietary oils tested.
KW - 8-Hydroxy-deoxyguanosine
KW - C3H/MeN mice
KW - Glyoxal
KW - Liver cancer
KW - Malonaldehyde
KW - Oxidized dietary oils
UR - http://www.scopus.com/inward/record.url?scp=4444306901&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2004.06.011
DO - 10.1016/j.fct.2004.06.011
M3 - Article
C2 - 15350677
AN - SCOPUS:4444306901
SN - 0278-6915
VL - 42
SP - 1795
EP - 1803
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
IS - 11
ER -