TY - JOUR
T1 - Low-level light therapy using a helmet-type device for the treatment of androgenetic alopecia:A 16-week, multicenter, randomized, double-blind, sham device-controlled trial
AU - Yoon, Jung Soo
AU - Ku, Won Young
AU - Lee, Jang Hyun
AU - Ahn, Hee Chang
N1 - Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.
PY - 2020/7/17
Y1 - 2020/7/17
N2 - IntroductionAndrogenetic alopecia is the most common form of hair loss in both sexes. In recent studies, low-level light therapy (LLLT) has been established as an effective treatment for alopecia. The purpose of this study was to evaluate the safety and efficacy of LLLT using a new helmet-type device for the treatment of androgenetic alopecia.MethodA randomized, sham device-controlled, double-blind clinical trial was conducted at 2 institutions. Sixty participants diagnosed with androgenetic alopecia aged from 19 to 65 years were recruited. LLLT was performed through a helmet-type device that emitted light with a mean output power of 2.36 mW/cm2at a wavelength of 655 nm. Participants were divided into 2 groups, which respectively used the experimental device and a sham device. After tattooing at the central point of the vertex, phototrichograms at that point were obtained at 0, 8, and 16 weeks. The primary endpoint of the study was the difference in the rate of change of hair density between the test group and the control group.ResultsComparing the results at baseline and week 16, the experimental group showed an increase in hair density of 41.90 hairs/cm2and an increase in hair thickness of 7.50 μm, whereas the control group showed an increase of 0.72 hairs/cm2and a decrease of 15.03 μm, respectively (P < .001). No adverse events or side effects occurred.ConclusionLLLT showed a significant effect on increasing hair density in patients with androgenetic alopecia. LLLT could be a safe and effective treatment for androgenetic alopecia in both sexes.
AB - IntroductionAndrogenetic alopecia is the most common form of hair loss in both sexes. In recent studies, low-level light therapy (LLLT) has been established as an effective treatment for alopecia. The purpose of this study was to evaluate the safety and efficacy of LLLT using a new helmet-type device for the treatment of androgenetic alopecia.MethodA randomized, sham device-controlled, double-blind clinical trial was conducted at 2 institutions. Sixty participants diagnosed with androgenetic alopecia aged from 19 to 65 years were recruited. LLLT was performed through a helmet-type device that emitted light with a mean output power of 2.36 mW/cm2at a wavelength of 655 nm. Participants were divided into 2 groups, which respectively used the experimental device and a sham device. After tattooing at the central point of the vertex, phototrichograms at that point were obtained at 0, 8, and 16 weeks. The primary endpoint of the study was the difference in the rate of change of hair density between the test group and the control group.ResultsComparing the results at baseline and week 16, the experimental group showed an increase in hair density of 41.90 hairs/cm2and an increase in hair thickness of 7.50 μm, whereas the control group showed an increase of 0.72 hairs/cm2and a decrease of 15.03 μm, respectively (P < .001). No adverse events or side effects occurred.ConclusionLLLT showed a significant effect on increasing hair density in patients with androgenetic alopecia. LLLT could be a safe and effective treatment for androgenetic alopecia in both sexes.
KW - androgenetic alopecia
KW - efficacy
KW - low-level light therapy
KW - randomized double-blind clinical trial
KW - safety
UR - http://www.scopus.com/inward/record.url?scp=85088503831&partnerID=8YFLogxK
U2 - 10.1097/MD.0000000000021181
DO - 10.1097/MD.0000000000021181
M3 - Article
C2 - 32702878
AN - SCOPUS:85088503831
SN - 0025-7974
VL - 99
SP - E21181
JO - Medicine (United States)
JF - Medicine (United States)
IS - 29
ER -