Abstract
Maackiapterocarpan B, one of the pterocarpan analogs found in Sophora tonkinensis, is known to display pharmacological activities. However, the anti-inflammatory effects of maackiapterocarpan B and its molecular mechanism have yet to be clearly elucidated. In the present study, the effects of maackiapterocarpan B on macrophage-mediated inflammation in vitro were assessed. Maackiapterocarpan B inhibited the production of nitric oxide, the expression of tumor necrosis factor α, colony stimulating factor 2, interleukin-1β and interleukin-6, and the activation of nuclear factor-κB and mitogen-activated protein kinases in lipopolysaccharide-stimulated macrophages. These observations suggest the potential of maackiapterocarpan B in the treatment of inflammatory diseases.
Original language | English |
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Pages (from-to) | 259-266 |
Number of pages | 8 |
Journal | Biological and Pharmaceutical Bulletin |
Volume | 39 |
Issue number | 2 |
DOIs | |
State | Published - 2016 |
Keywords
- Maackiapterocarpan B
- Macrophage
- Mitogen-activated protein kinase
- Nitric oxide
- Nuclear factor kappa B