Maackiapterocarpan B from Sophora tonkinensis suppresses inflammatory mediators via nuclear factor-κB and mitogen-activated protein kinase pathways

Hee Sung Chae, Hunseung Yoo, Young Hee Choi, Won Jun Choi, Young Won Chin

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Maackiapterocarpan B, one of the pterocarpan analogs found in Sophora tonkinensis, is known to display pharmacological activities. However, the anti-inflammatory effects of maackiapterocarpan B and its molecular mechanism have yet to be clearly elucidated. In the present study, the effects of maackiapterocarpan B on macrophage-mediated inflammation in vitro were assessed. Maackiapterocarpan B inhibited the production of nitric oxide, the expression of tumor necrosis factor α, colony stimulating factor 2, interleukin-1β and interleukin-6, and the activation of nuclear factor-κB and mitogen-activated protein kinases in lipopolysaccharide-stimulated macrophages. These observations suggest the potential of maackiapterocarpan B in the treatment of inflammatory diseases.

Original languageEnglish
Pages (from-to)259-266
Number of pages8
JournalBiological and Pharmaceutical Bulletin
Volume39
Issue number2
DOIs
StatePublished - 2016

Keywords

  • Maackiapterocarpan B
  • Macrophage
  • Mitogen-activated protein kinase
  • Nitric oxide
  • Nuclear factor kappa B

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