Mass spectrometry assisted lithography for the patterning of cell adhesion ligands on self-assembled monolayers

Young Kwan Kim, Soo N. Ryoo, Sul Jin Kwack, Dal Hee Min

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Pattern of events: A simple and flexible method has been developed for patterning cell adhesion ligands. Locally erasing self-assembled monolayers with tri(ethyleneglycol) groups on a gold substrate by using a MALDI-TOF MS nitrogen laser and filling the exposed gold surface with an alkanethiol presenting carboxylic acid groups enables subsequent immobilization of maleimide and a cell adhesion peptide, which can then recognize cells (see scheme).

Original languageEnglish
Pages (from-to)3507-3511
Number of pages5
JournalAngewandte Chemie - International Edition
Volume48
Issue number19
DOIs
StatePublished - 27 Apr 2009

Keywords

  • Cell adhesion
  • Fluorescence imaging
  • Lithography
  • Mass spectrometry
  • Monolayers

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