Matrix-Incorporated Polydopamine Layer as a Simple, Efficient, and Universal Coating for Laser Desorption/Ionization Time-of-Flight Mass Spectrometric Analysis

Young Kwan Kim, Ryan Landis, Richard W. Vachet, Vincent M. Rotello

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Self-oxidative copolymerization of dopamine with α-cyano-4-hydroxycinnamic acid (CHCA) provides an efficient and multifunctional platform for laser desorption/ionization time-of-flight mass spectrometry (LDI-TOF-MS) analysis. The polydopamine coating layer embedded with the CHCA matrix can be readily formed on nanomaterials and solid substrates without additional surface treatments to generate an efficient LDI-TOF-MS platform for the analysis of small molecules as well as synthetic polymers. This coating can be further functionalized with specific ligands for target enrichment from complex biological media, providing analyte capture for subsequent LDI-TOF-MS analysis.

Original languageEnglish
Pages (from-to)36361-36368
Number of pages8
JournalACS Applied Materials and Interfaces
Volume10
Issue number42
DOIs
StatePublished - 24 Oct 2018

Keywords

  • coating
  • dopamine
  • enrichment
  • hybrid
  • mass spectrometry
  • matrix

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